A Novel Implanted Device to Wirelessly Record and Analyze Continuous Intracranial Canine EEG

Overview

Journal Epilepsy Res

Specialty Neurology

Date 2011 Jun 17

PMID 21676591

Citations 41

Authors

Kathryn A Davis

Beverly K Sturges

Charles H Vite

Vanessa Ruedebusch

Gregory Worrell

Andrew B Gardner

Kent Leyde

W Douglas Sheffield

Brian Litt

Affiliations

Soon will be listed here.

Abstract

We present results from continuous intracranial electroencephalographic (iEEG) monitoring in 6 dogs with naturally occurring epilepsy, a disorder similar to the human condition in its clinical presentation, epidemiology, electrophysiology and response to therapy. Recordings were obtained using a novel implantable device wirelessly linked to an external, portable real-time processing unit. We demonstrate previously uncharacterized intracranial seizure onset patterns in these animals that are strikingly similar in appearance to human partial onset epilepsy. We propose: (1) canine epilepsy as an appropriate model for testing human antiepileptic devices and new approaches to epilepsy surgery, and (2) this new technology as a versatile platform for evaluating seizures and response to therapy in the natural, ambulatory setting.

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References

Blum D, Eskola J, Bortz J, Fisher R . Patient awareness of seizures. Neurology. 1996; 47(1):260-4. DOI: 10.1212/wnl.47.1.260. View

Chandler K . Canine epilepsy: what can we learn from human seizure disorders?. Vet J. 2005; 172(2):207-17. DOI: 10.1016/j.tvjl.2005.07.001. View

Pellegrino F, Sica R . Canine electroencephalographic recording technique: findings in normal and epileptic dogs. Clin Neurophysiol. 2004; 115(2):477-87. DOI: 10.1016/s1388-2457(03)00347-x. View

Ben-Menachem E . Vagus-nerve stimulation for the treatment of epilepsy. Lancet Neurol. 2003; 1(8):477-82. DOI: 10.1016/s1474-4422(02)00220-x. View

Platt S, Adams V, Garosi L, Abramson C, Penderis J, De Stefani A . Treatment with gabapentin of 11 dogs with refractory idiopathic epilepsy. Vet Rec. 2006; 159(26):881-4. View

Smith S . EEG in the diagnosis, classification, and management of patients with epilepsy. J Neurol Neurosurg Psychiatry. 2005; 76 Suppl 2:ii2-7. PMC: 1765691. DOI: 10.1136/jnnp.2005.069245. View

Munana K, Vitek S, Tarver W, Saito M, Skeen T, Sharp N . Use of vagal nerve stimulation as a treatment for refractory epilepsy in dogs. J Am Vet Med Assoc. 2002; 221(7):977-83. DOI: 10.2460/javma.2002.221.977. View

Kwan P, Brodie M . Epilepsy after the first drug fails: substitution or add-on?. Seizure. 2000; 9(7):464-8. DOI: 10.1053/seiz.2000.0442. View

Berendt M, Hogenhaven H, Flagstad A, Dam M . Electroencephalography in dogs with epilepsy: similarities between human and canine findings. Acta Neurol Scand. 1999; 99(5):276-83. DOI: 10.1111/j.1600-0404.1999.tb00676.x. View

10.

Jeserevics J, Viitmaa R, Cizinauskas S, Sainio K, Jokinen T, Snellman M . Electroencephalography findings in healthy and Finnish Spitz dogs with epilepsy: visual and background quantitative analysis. J Vet Intern Med. 2008; 21(6):1299-306. DOI: 10.1892/06-285.1. View

11.

von Klopmann T, Rambeck B, Tipold A . Prospective study of zonisamide therapy for refractory idiopathic epilepsy in dogs. J Small Anim Pract. 2007; 48(3):134-8. DOI: 10.1111/j.1748-5827.2006.00290.x. View

12.

Noe K, Drazkowski J . Safety of long-term video-electroencephalographic monitoring for evaluation of epilepsy. Mayo Clin Proc. 2009; 84(6):495-500. PMC: 2688622. DOI: 10.4065/84.6.495. View

13.

Platt S, Haag M . Canine status epilepticus: a retrospective study of 50 cases. J Small Anim Pract. 2002; 43(4):151-3. DOI: 10.1111/j.1748-5827.2002.tb00047.x. View

14.

Berendt M, Gram L . Epilepsy and seizure classification in 63 dogs: a reappraisal of veterinary epilepsy terminology. J Vet Intern Med. 1999; 13(1):14-20. View

15.

Volk H, Matiasek L, Lujan Feliu-Pascual A, Platt S, Chandler K . The efficacy and tolerability of levetiracetam in pharmacoresistant epileptic dogs. Vet J. 2007; 176(3):310-9. DOI: 10.1016/j.tvjl.2007.03.002. View

16.

Kenney C, Simpson R, Hunter C, Ondo W, Almaguer M, Davidson A . Short-term and long-term safety of deep brain stimulation in the treatment of movement disorders. J Neurosurg. 2007; 106(4):621-5. DOI: 10.3171/jns.2007.106.4.621. View

17.

Fisher R, Salanova V, Witt T, Worth R, Henry T, Gross R . Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy. Epilepsia. 2010; 51(5):899-908. DOI: 10.1111/j.1528-1167.2010.02536.x. View