Simultaneous Integrated Boost for Adjuvant Treatment of Breast Cancer--intensity Modulated Vs. Conventional Radiotherapy: the IMRT-MC2 Trial

Overview

Journal BMC Cancer

Publisher Biomed Central

Specialty Oncology

Date 2011 Jun 17

PMID 21676232

Citations 11

Authors

Vasileios Askoxylakis

Alexandra D Jensen

Matthias F Hafner

Leonie Fetzner

Florian Sterzing

Joerg Heil

Christof Sohn

Johannes Husing

Uta Tiefenbacher

Frederik Wenz

Jurgen Debus

Holger Hof

Affiliations

Soon will be listed here.

Abstract

Background: Radiation therapy is an essential modality in the treatment of breast cancer. Addition of radiotherapy to surgery has significantly increased local control and survival rates of the disease. However, radiotherapy is also associated with side effects, such as tissue fibrosis or enhanced vascular morbidity. Modern radiotherapy strategies, such as intensity modulated radiotherapy (IMRT), can shorten the overall treatment time by integration of the additional tumor bed boost significantly. To what extent this might be possible without impairing treatment outcome and cosmetic results remains to be clarified.

Methods/design: The IMRT-MC2 study is a prospective, two armed, multicenter, randomized phase-III-trial comparing intensity modulated radiotherapy with integrated boost to conventional radiotherapy with consecutive boost in patients with breast cancer after breast conserving surgery. 502 patients will be recruited and randomized into two arms: patients in arm A will receive IMRT in 28 fractions delivering 50.4 Gy to the breast and 64.4 Gy to the tumor bed by integrated boost, while patients in arm B will receive conventional radiotherapy of the breast in 28 fractions to a dose of 50.4 Gy and consecutive boost in 8 fractions to a total dose of 66.4 Gy.

Discussion: Primary objectives of the study are the evaluation of the cosmetic results 6 weeks and 2 years post treatment and the 2- and 5-year local recurrence rates for the two different radiotherapy strategies. Secondary objectives are long term overall survival, disease free survival and quality of life.

Trial Registration: ClinicalTrials.gov Protocol ID: NCT01322854.

Citing Articles

Intensity-modulated radiation therapy for early-stage breast cancer: a systematic review and meta-analysis.

Hanna S, Mota B, Moraes F, Marta G, Carvalho H, Riera R Sao Paulo Med J. 2025; 143(1):e2023324.

PMID: 39774728 PMC: 11655040. DOI: 10.1590/1516-3180.2023.0324.R1.03072024.

Methods of Esthetic Assessment after Adjuvant Whole-Breast Radiotherapy in Breast Cancer Patients: Evaluation of the BCCT.core Software and Patients' and Physicians' Assessment from the Randomized IMRT-MC2 Trial.

Forster T, Kohler C, Dorn M, Hafner M, Arians N, Konig L Cancers (Basel). 2022; 14(12).

PMID: 35740675 PMC: 9221255. DOI: 10.3390/cancers14123010.

Radiodermatitis and Fibrosis in the Context of Breast Radiation Therapy: A Critical Review.

Allali S, Kirova Y Cancers (Basel). 2021; 13(23).

PMID: 34885037 PMC: 8656525. DOI: 10.3390/cancers13235928.

Acute toxicity of normofractionated intensity modulated radiotherapy with simultaneous integrated boost compared to three-dimensional conformal radiotherapy with sequential boost in the adjuvant treatment of breast cancer.

Krug D, Koder C, Hafner M, Arians N, Harrabi S, Koerber S Radiat Oncol. 2020; 15(1):235.

PMID: 33050920 PMC: 7557053. DOI: 10.1186/s13014-020-01652-x.

Hypofractionation with concomitant boost using intensity-modulated radiation therapy in early-stage breast cancer in Mexico.

Hernandez M, Lujan Castilla P, Quezada Bautista A Rep Pract Oncol Radiother. 2018; 23(4):276-283.

PMID: 30090027 PMC: 6078106. DOI: 10.1016/j.rpor.2018.06.006.

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