Differential Effects of Dietary Canola and Soybean Oil Intake on Oxidative Stress in Stroke-prone Spontaneously Hypertensive Rats

Overview

Journal Lipids Health Dis

Publisher Biomed Central

Specialties Biochemistry
Endocrinology

Date 2011 Jun 15

PMID 21669000

Citations 9

Authors

Annateresa Papazzo

Xavier A Conlan

Louise Lexis

Paul A Lewandowski

Affiliations

Soon will be listed here.

Abstract

Background: Canola oil shortens the life span of stroke-prone spontaneously hypertensive (SHRSP) rats compared with rats fed soybean oil when given as the sole dietary lipid source. One possible mechanism leading to the damage and deterioration of organs due to canola oil ingestion is oxidative stress. This study investigated the effect of canola oil intake on oxidative stress in this animal model.

Method: Male SHRSP rats, were fed a defatted control diet containing 10% wt/wt soybean oil or a defatted treatment diet containing 10% wt/wt canola oil, and given water containing 1% NaCl. Blood pressure was measured weekly. Blood was collected prior to beginning the diets and at the end of completion of the study for analysis of red blood cell (RBC) antioxidant enzymes, RBC and plasma malondialdehyde (MDA), plasma 8-isoprostane and plasma lipids.

Results: Canola oil ingestion significantly decreased the life span of SHRSP rats compared with soybean oil, 85.8 ± 1.1 and 98.3 ± 3.4 days, respectively. Systolic blood pressure increased over time with a significant difference between the diets at the 6th week of feeding. Canola oil ingestion significantly reduced RBC superoxide dismutase, glutathione peroxidase and catalase activities, total cholesterol and low-density lipoprotein cholesterol compared with soybean oil. There were no significant differences in RBC MDA concentration between canola oil fed and soybean oil fed rats. In contrast, plasma MDA and 8-isoprostane concentration was significantly lower in the canola oil group compared to the soybean oil group.

Conclusion: In conclusion, canola oil ingestion shortens the life span of SHRSP rats and leads to changes in oxidative status, despite an improvement in the plasma lipids.

Citing Articles

Effects of Consuming Repeatedly Heated Edible Oils on Cardiovascular Diseases: A Narrative Review.

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Rapeseed (canola) oil aggravates metabolic syndrome-like conditions in male but not in female stroke-prone spontaneously hypertensive rats (SHRSP).

Nishikawa M, Ohara N, Naito Y, Saito Y, Amma C, Tatematsu K Toxicol Rep. 2022; 9:256-268.

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Fully hydrogenated canola oil extends lifespan in stroke-prone spontaneously hypertensive rats.

Tatematsu K, Miyazawa D, Saito Y, Okuyama H, Ohara N Lipids Health Dis. 2021; 20(1):102.

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The Dietary Replacement of Soybean Oil by Canola Oil Does Not Prevent Liver Fatty Acid Accumulation and Liver Inflammation in Mice.

Antunes M, Godoy G, Fernandes I, Manin L, Zappielo C, Masi L Nutrients. 2020; 12(12).

PMID: 33260679 PMC: 7760057. DOI: 10.3390/nu12123667.

Effect of canola oil consumption on memory, synapse and neuropathology in the triple transgenic mouse model of Alzheimer's disease.

Lauretti E, Pratico D Sci Rep. 2017; 7(1):17134.

PMID: 29215028 PMC: 5719422. DOI: 10.1038/s41598-017-17373-3.

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