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Central Nervous System Involvement in Diabetic Neuropathy

Overview
Journal Curr Diab Rep
Publisher Current Science
Specialty Endocrinology
Date 2011 Jun 14
PMID 21667355
Citations 42
Authors
Affiliations
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Abstract

Diabetic neuropathy is a chronic and often disabling condition that affects a significant number of individuals with diabetes. Long considered a disease of the peripheral nervous system, there is now increasing evidence of central nervous system involvement. Recent advances in neuroimaging methods detailed in this review have led to a better understanding and refinement of how diabetic neuropathy affects the central nervous system. Recognition that diabetic neuropathy is, in part, a disease that affects the whole nervous system is resulting in a critical rethinking of this disorder, opening a new direction for further research.

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References
1.
Davies M, Brophy S, Williams R, Taylor A . The prevalence, severity, and impact of painful diabetic peripheral neuropathy in type 2 diabetes. Diabetes Care. 2006; 29(7):1518-22. DOI: 10.2337/dc05-2228. View

2.
Hsieh J, Belfrage M, Stone-Elander S, Hansson P, Ingvar M . Central representation of chronic ongoing neuropathic pain studied by positron emission tomography. Pain. 1995; 63(2):225-236. DOI: 10.1016/0304-3959(95)00048-W. View

3.
Pfeifer M, Schumer M . Clinical trials of diabetic neuropathy: past, present, and future. Diabetes. 1995; 44(12):1355-61. DOI: 10.2337/diab.44.12.1355. View

4.
Britland S, Young R, Sharma A, Clarke B . Acute and remitting painful diabetic polyneuropathy: a comparison of peripheral nerve fibre pathology. Pain. 1992; 48(3):361-370. DOI: 10.1016/0304-3959(92)90085-P. View

5.
Forsblom C, Sane T, Groop P, Totterman K, Kallio M, Saloranta C . Risk factors for mortality in Type II (non-insulin-dependent) diabetes: evidence of a role for neuropathy and a protective effect of HLA-DR4. Diabetologia. 1998; 41(11):1253-62. DOI: 10.1007/s001250051062. View