Transformation of Follicular Lymphoma

Overview

Journal Best Pract Res Clin Haematol

Publisher Elsevier

Specialty Hematology

Date 2011 Jun 11

PMID 21658615

Citations 60

Authors

Izidore S Lossos

Randy D Gascoyne

Affiliations

Soon will be listed here.

Abstract

Histological transformation of follicular lymphoma (FL) to a more aggressive non-Hodgkin's lymphomas is a pivotal event in the natural history of FL and is associated with poor outcome. While commonly observed in clinical practice and despite multiple studies designed to address its pathogenesis, the biology of this process represents an enigma. In this chapter we present a state of the art review summarizing the definition of histologic transformation, its incidence, pathogenesis, clinical manifestations, treatment and outcome. Furthermore, we specifically emphasize gaps in our knowledge that should be addressed in future studies.

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