Paced-mating Increases the Number of Adult New Born Cells in the Internal Cellular (granular) Layer of the Accessory Olfactory Bulb

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2011 Jun 4

PMID 21637743

Citations 15

Authors

Rebeca Corona

Jorge Larriva-Sahd

Raul G Paredes

Affiliations

Soon will be listed here.

Abstract

The continuous production and addition of new neurons during life in the olfactory bulb is well accepted and has been extensively studied in rodents. This process could allow the animals to adapt to a changing environment. Olfactory neurogenesis begins in the subventricular zone where stem cells proliferate and give rise to young undifferentiated neuroblasts that migrate along the rostral migratory stream to the olfactory bulb (OB). Olfaction is crucial for the expression of sexual behavior in rodents. In female rats, the ability to control the rate of sexual interactions (pacing) has important physiological and behavioral consequences. In the present experiment we evaluated if pacing behavior modifies the rate of new cells that reach the main and accessory olfactory bulb. The BrdU marker was injected before and after different behavioral tests which included: females placed in a mating cage (control), females allowed to pace the sexual interaction, females that mated but were not able to control the rate of the sexual interaction and females exposed to a sexually active male. Subjects were sacrificed fifteen days after the behavioral test. We observed a significant increase in the density of BrdU positive cells in the internal cellular layer of the accessory olfactory bulb when females paced the sexual interaction in comparison to the other 3 groups. No differences in the cell density in the main olfactory bulb were found. These results suggest that pacing behavior promotes an increase in density of the new cells in the accessory olfactory bulb.

Citing Articles

Linking Adult Olfactory Neurogenesis to Social Reproductive Stimuli: Mechanisms and Functions.

Bovetti S, Bonzano S, Luzzati F, Dati C, De Marchis S, Peretto P Int J Mol Sci. 2025; 26(1.

PMID: 39796023 PMC: 11720170. DOI: 10.3390/ijms26010163.

Mating-induced prolactin surge is not required for subsequent neurogenesis in male mice.

Smiley K, Phillipps H, Fang C, Brown R, Grattan D Front Behav Neurosci. 2023; 17:1227726.

PMID: 37484521 PMC: 10356981. DOI: 10.3389/fnbeh.2023.1227726.

Repeated Paced Mating Increases the Survival of New Neurons in the Accessory Olfactory Bulb.

Portillo W, Ortiz G, Paredes R Front Neurosci. 2020; 14:249.

PMID: 32265646 PMC: 7105896. DOI: 10.3389/fnins.2020.00249.

Neurogenesis in the olfactory bulb induced by paced mating in the female rat is opioid dependent.

Santoyo-Zedillo M, Portillo W, Paredes R PLoS One. 2017; 12(11):e0186335.

PMID: 29107945 PMC: 5673160. DOI: 10.1371/journal.pone.0186335.

Sexual Stimulation Increases the Survival of New Cells in the Accessory Olfactory Bulb of the Male Rat.

Unda N, Portillo W, Corona R, Paredes R Front Neurosci. 2016; 10:65.

PMID: 26973447 PMC: 4771754. DOI: 10.3389/fnins.2016.00065.

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