Neural Stem Cell Niches: Roles for the Hyaluronan-based Extracellular Matrix

Overview

Journal Front Biosci (Schol Ed)

Specialty Biology

Date 2011 May 31

PMID 21622263

Citations 67

Authors

Marnie Preston

Larry S Sherman

Affiliations

Soon will be listed here.

Abstract

Neural stem/progenitor cells capable of differentiating into the neurons and glial cells that populate the mammalian central nervous system (CNS) persist in specific neural stem cell niches that regulate stem cell proliferation, survival and differentiation. There is growing evidence that the extracellular matrix within neural stem cell niches is required for neural stem cell maintenance. Here, we review findings supporting a pivotal role for the glycosaminoglycan hyaluronan (HA) and its transmembrane receptors in neural stem/progenitor cell proliferation, differentiation and maturation. We also outline findings supporting changing roles for HA as cells become committed to distinct lineages in the brain and spinal cord.

Citing Articles

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