Organic Matrix-related Mineralization of Sea Urchin Spicules, Spines, Test and Teeth

Overview

Journal Front Biosci (Landmark Ed)

Specialty Biology

Date 2011 May 31

PMID 21622194

Citations 8

Authors

Arthur Veis

Affiliations

Soon will be listed here.

Abstract

The camarodont echinoderms have five distinct mineralized skeletal elements: embryonic spicules, mature test, spines, lantern stereom and teeth. The spicules are transient structural elements whereas the spines, and test plates are permanent. The teeth grow continuously. The mineral is a high magnesium calcite, but the magnesium content is different in each type of skeletal element, varying from 5 to 40 mole% Mg. The organic matrix creates the spaces and environments for crystal initiation and growth. The detailed mechanisms of crystal regulation are not known, but acidic and phosphorylated matrix proteins may be of special importance. Biochemical studies, sequencing of the complete genome, and high-throughput proteomic analysis have not yet provided insight into the mechanisms of crystallization, calcite composition, and orientation applicable to all skeletal elements. The embryonic spicules are not representative of the mature skeletal elements. The next phase of research will have to focus on the specific localization of the proteins and individual biochemistries of each system with regard to mineral content and placement.

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References

Gotliv B, Addadi L, Weiner S . Mollusk shell acidic proteins: in search of individual functions. Chembiochem. 2003; 4(6):522-9. DOI: 10.1002/cbic.200200548. View

Alvares K, Dixit S, Lux E, Veis A . Echinoderm phosphorylated matrix proteins UTMP16 and UTMP19 have different functions in sea urchin tooth mineralization. J Biol Chem. 2009; 284(38):26149-60. PMC: 2758014. DOI: 10.1074/jbc.M109.024018. View

Mann K, Poustka A, Mann M . In-depth, high-accuracy proteomics of sea urchin tooth organic matrix. Proteome Sci. 2008; 6:33. PMC: 2614417. DOI: 10.1186/1477-5956-6-33. View

Veis D, Albinger T, Clohisy J, Rahima M, Sabsay B, Veis A . Matrix proteins of the teeth of the sea urchin Lytechinus variegatus. J Exp Zool. 1986; 240(1):35-46. DOI: 10.1002/jez.1402400106. View

Anstrom J, Chin J, Leaf D, Parks A, Raff R . Localization and expression of msp130, a primary mesenchyme lineage-specific cell surface protein in the sea urchin embryo. Development. 1987; 101(2):255-65. DOI: 10.1242/dev.101.2.255. View

Holland N . AN AUTORADIOGRAPHIC INVESTIGATION OF TOOTH RENEWAL IN THE PURPLE SEA URCHIN (STRONGYLOCENTROTUS PURPURATUS). J Exp Zool. 1965; 158:275-81. DOI: 10.1002/jez.1401580304. View

Veis A, Barss J, Dahl T, Rahima M, Stock S . Mineral-related proteins of sea urchin teeth: Lytechinus variegatus. Microsc Res Tech. 2002; 59(5):342-51. DOI: 10.1002/jemt.10216. View

Heatfield B, TRAVIS D . Ultrastructural studies of regenerating spines of the sea urchin Strongylocentrotus purpuratus. I. Cell types without spherules. J Morphol. 1975; 145(1):13-49. DOI: 10.1002/jmor.1051450103. View

Bottjer D, Davidson E, Peterson K, Cameron R . Paleogenomics of echinoderms. Science. 2006; 314(5801):956-60. DOI: 10.1126/science.1132310. View

10.

Killian C, WILT F . Characterization of the proteins comprising the integral matrix of Strongylocentrotus purpuratus embryonic spicules. J Biol Chem. 1996; 271(15):9150-9. DOI: 10.1074/jbc.271.15.9150. View

11.

Robach J, Stock S, Veis A . Structure of first- and second-stage mineralized elements in teeth of the sea urchin Lytechinus variegatus. J Struct Biol. 2009; 168(3):452-66. PMC: 2783381. DOI: 10.1016/j.jsb.2009.07.013. View

12.

Poustka A, Kuhn A, Groth D, Weise V, Yaguchi S, Burke R . A global view of gene expression in lithium and zinc treated sea urchin embryos: new components of gene regulatory networks. Genome Biol. 2007; 8(5):R85. PMC: 1929154. DOI: 10.1186/gb-2007-8-5-r85. View

13.

Venkatesan M, Simpson R . Isolation and characterization of spicule proteins from Strongylocentrotus purpuratus. Exp Cell Res. 1986; 166(1):259-64. DOI: 10.1016/0014-4827(86)90526-4. View

14.

Mann K, Poustka A, Mann M . Phosphoproteomes of Strongylocentrotus purpuratus shell and tooth matrix: identification of a major acidic sea urchin tooth phosphoprotein, phosphodontin. Proteome Sci. 2010; 8(1):6. PMC: 2830187. DOI: 10.1186/1477-5956-8-6. View

15.

Morrissey J . Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. Anal Biochem. 1981; 117(2):307-10. DOI: 10.1016/0003-2697(81)90783-1. View

16.

Mann K, Wilt F, Poustka A . Proteomic analysis of sea urchin (Strongylocentrotus purpuratus) spicule matrix. Proteome Sci. 2010; 8:33. PMC: 2909932. DOI: 10.1186/1477-5956-8-33. View

17.

Veis A, SCHLUETER R . THE MACROMOLECULAR ORGANIZATION OF DENTINE MATRIX COLLAGEN. I. CHARACTERIZATION OF DENTINE COLLAGEN. Biochemistry. 1964; 3:1650-7. DOI: 10.1021/bi00899a009. View

18.

Weiner S . Organic matrixlike macromolecules associated with the mineral phase of sea urchin skeletal plates and teeth. J Exp Zool. 1985; 234(1):7-15. DOI: 10.1002/jez.1402340103. View

19.

Dyson H, Wright P . Intrinsically unstructured proteins and their functions. Nat Rev Mol Cell Biol. 2005; 6(3):197-208. DOI: 10.1038/nrm1589. View

20.

Veis A, Perry A . The phosphoprotein of the dentin matrix. Biochemistry. 1967; 6(8):2409-16. DOI: 10.1021/bi00860a017. View