Cognitive Side Effects of Cancer Therapy Demonstrate a Functional Role for Adult Neurogenesis

Overview

Journal Behav Brain Res

Specialties Neurology
Psychology
Social Sciences

Date 2011 May 31

PMID 21621557

Citations 90

Authors

Michelle Monje

Jorg Dietrich

Affiliations

Soon will be listed here.

Abstract

Cancer therapies frequently result in a spectrum of neurocognitive deficits that include impaired learning, memory, attention and speed of information processing. Damage to dynamic neural progenitor cell populations in the brain are emerging as important etiologic factors. Radiation and chemotherapy-induced damage to neural progenitor populations responsible for adult hippocampal neurogenesis and for maintenance of subcortical white matter integrity are now believed to play major roles in the neurocognitive impairment many cancer survivors experience.

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