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Heterogeneity of Altered Cytokine Levels Across the Clinical Spectrum of Diabetes in China

Overview
Journal Diabetes Care
Specialty Endocrinology
Date 2011 May 28
PMID 21617097
Citations 23
Authors
Yufei Xiang
Pengcheng Zhou
Xiaojue Li
Gan Huang
Zhenqi Liu
Aimin Xu
R David Leslie
Zhiguang Zhou
Affiliations
Soon will be listed here.
Abstract

Objective: To determine the relationship between selected cytokines and diabetes in Chinese subjects.

Research Design And Methods: Adult patients with recent-onset type 1 diabetes (n=53), latent autoimmune diabetes in adults (LADA) (n=250), and type 2 diabetes (n=285) from multiple centers were compared with normal subjects (n=196). We centrally tested serum GAD antibodies (GADAs), interleukin-6 (IL-6), lipocalin 2 (LCN2), high-sensitivity C-reactive protein (hs-CRP), and adiponectin.

Results: After adjustment for age, sex, and BMI, all diabetes types had increased IL-6 and LCN2 (P<0.01), and all four cytokines were increased in LADA (P<0.01). In type 1 diabetes, adiponectin but not hs-CRP was increased (P<0.01), whereas in type 2 diabetes, hs-CRP but not adiponectin was increased (P<0.01). Adiponectin was correlated positively with GADA titer and negatively with hs-CRP (P<0.01 for both).

Conclusions: In China, inflammatory markers are increased in all three major types of diabetes, but probably for different reasons, even in autoimmune diabetes.

Citing Articles

Identification of crucial extracellular genes as potential biomarkers in newly diagnosed Type 1 diabetes integrated bioinformatics analysis.

Gao M, Liu Q, Zhang L, Tabak F, Hua Y, Shao W PeerJ. 2025; 13():e18660.

PMID: 39802181 PMC: 11725270. DOI: 10.7717/peerj.18660.

Systemic Cytokine Expression in Diabetes Is Associated with Prolonged Gastrointestinal Transit Times and Cardinal Gastroparesis Symptoms.

Okdahl T, Wegeberg A, Jensen A, Jensen S, Andersen H, Storling J Biomedicines. 2023; 11(4).

PMID: 37189645 PMC: 10136139. DOI: 10.3390/biomedicines11041027.

Variable frequencies of peripheral T-lymphocyte subsets in the diabetes spectrum from type 1 diabetes through latent autoimmune diabetes in adults (LADA) to type 2 diabetes.

Tan T, Xiang Y, Deng C, Cao C, Ren Z, Huang G Front Immunol. 2022; 13:974864.

PMID: 36091068 PMC: 9449581. DOI: 10.3389/fimmu.2022.974864.

Latent autoimmune diabetes in adults in China.

Qiu J, Xiao Z, Zhang Z, Luo S, Zhou Z Front Immunol. 2022; 13:977413.

PMID: 36090989 PMC: 9454334. DOI: 10.3389/fimmu.2022.977413.

Adult-onset autoimmune diabetes identified by glutamic acid decarboxylase autoantibodies: a retrospective cohort study.

Wada E, Onoue T, Kinoshita T, Hayase A, Handa T, Ito M Diabetologia. 2021; 64(10):2183-2192.

PMID: 34268631 DOI: 10.1007/s00125-021-05516-1.

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