Relationship Between Plasma Adiponectin, Retinol-binding Protein 4 and Uric Acid in Hypertensive Patients with Metabolic Syndrome

Overview

Journal Korean Circ J

Date 2011 May 25

PMID 21607170

Citations 4

Authors

Chan Seok Park

Sang-Hyun Ihm

Hun-Jun Park

Woo-Seung Shin

Pum-Jun Kim

Kiyuk Chang

Hee-Yeol Kim

Ho-Joong Youn

Wook-Sung Chung

Ki Bae Seung

Jae-Hyung Kim

Affiliations

Soon will be listed here.

Abstract

Background And Objectives: Adipokines have been suggested for their potential use in tracking the clinical progress in the subjects with metabolic syndrome (MS). To investigate the relationship between the serum levels of adipokines {adiponectin and retinol-binding protein 4 (RBP4)} and the serum level of uric acid in hypertensive (HTN) patients with MS.

Subjects And Methods: In this study, 38 totally untreated HTN patients were enrolled. Anthropometric measurements, blood pressure (BP) were taken in the 12 HTN patients without MS and the 26 HTN patients with MS. Fasting blood samples were collected for measurement of adiponectin, RBP4, nitric oxide (NO), glucose, creatinine, uric acid, lipid profile and insulin.

Results: The HTN with MS group had significant higher values of body mass index, waist length, serum uric acid and triglyceride levels than the HTN without MS group. Compared to the HTN without MS group, the HTN with MS group showed significantly lower adiponectin (p=0.030), NO (p=0.003) and high density lipoprotein levels (p<0.001). Serum adiponectin levels negatively correlated with insulin level (R=-0.453, p=0.026) and uric acid level (R=-0.413, p=0.036), and serum RBP4 levels positively correlated with uric acid level (R=0.527, p=0.006) in the HTN with MS group. Multiple linear regression analysis using RBP4 and adiponectin levels as the dependent variables showed that uric acid level correlated with serum RBP4 level (p=0.046) and adiponectin level (p=0.044).

Conclusion: The HTN with MS group showed a correlation with two types of adipokines (adiponectin, RBP4) and uric acid. Adiponectin, RBP4 and uric acid may be important components associated with MS, especially when associated with hypertension.

Citing Articles

Associaton of Retinol Binding Protein 4 (RBP4) Levels With Hyperuricemia: A Cross-Sectional Study in a Chinese Population.

Hong G, Shao X, Li J, Zhou Q, Ke X, Gao P Front Endocrinol (Lausanne). 2022; 13:879755.

PMID: 35846279 PMC: 9276999. DOI: 10.3389/fendo.2022.879755.

Components of metabolic syndrome in relation to plasma levels of retinol binding protein 4 (RBP4) in a cohort of people aged 65 years and older.

Majerczyk M, Kocelak P, Choreza P, Arabzada H, Owczarek A, Bozentowicz-Wikarek M J Endocrinol Invest. 2018; 41(10):1211-1219.

PMID: 29524177 PMC: 6182353. DOI: 10.1007/s40618-018-0856-6.

Uric acid upregulates the adiponectin‑adiponectin receptor 1 pathway in renal proximal tubule epithelial cells.

Yang Q, Fu C, Xiao J, Ye Z Mol Med Rep. 2018; 17(3):3545-3554.

PMID: 29359786 PMC: 5802152. DOI: 10.3892/mmr.2017.8315.

Reduced lung function is independently associated with increased risk of type 2 diabetes in Korean men.

Kwon C, Rhee E, Song J, Kim J, Kwag H, Sung K Cardiovasc Diabetol. 2012; 11:38.

PMID: 22524685 PMC: 3464774. DOI: 10.1186/1475-2840-11-38.

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