Metabolic Syndrome and Gastro-esophageal Reflux: A Link Towards a Growing Interest in Developed Countries

Overview

Journal World J Gastrointest Pathophysiol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2011 May 25

PMID 21607146

Citations 11

Authors

Enzo Ierardi

Rosa Rosania

Mariangela Zotti

Simonetta Principe

Giulio Laonigro

Floriana Giorgio

Vincenzo De Francesco

Carmine Panella

Affiliations

Soon will be listed here.

Abstract

The aim of this Editorial is to describe the growing possibility of a link between gastro-esophageal reflux disease (GERD) and metabolic syndrome on the light of recent epidemiological and pathophysiological evidence. The state of the art of GERD is described, based on recent definitions, pathophysiological evidence, epidemiology in developed countries, clinical subtypes together with a diagnostic approach specifically focussed on the appropriateness of endoscopy. Metabolic syndrome is accurately defined and the pivotal role of insulin resistance is emphasized. The strong relationship between GERD and metabolic syndrome has been pathophysiologically analyzed, taking into account the role of obesity, mechanical factors and metabolic changes. Data collected by our group regarding eating habits and GERD are briefly summarized at the end of a pathophysiological analysis. The literature on the subject strongly supports the possibility that lifestyle and eating habits may be involved in both GERD and metabolic syndrome in developed countries.

Citing Articles

Risk factors and 26-years worldwide prevalence of endoscopic erosive esophagitis from 1997 to 2022: a meta-analysis.

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The association between metabolic syndrome and erosive esophagitis: A systematic review and meta-analysis.

Azami M, Salamati M, Ranjbar R, Sahebkar A EXCLI J. 2021; 20:1532-1543.

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Proton-pump inhibitors associated with decreased urinary citrate excretion.

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PMID: 33206338 DOI: 10.1007/s11255-020-02719-0.

What is the impact of metabolic syndrome and its components on reflux esophagitis? A cross-sectional study.

Hsieh Y, Wu M, Yang P, Liao W, Hsieh Y, Chang Y BMC Gastroenterol. 2019; 19(1):33.

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Insulin Resistance is Associated with Chronic Laryngitis in Korean Women.

Cho J, Lee S, Han K, Joo Y J Nutr Health Aging. 2018; 22(4):471-475.

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