Vaccine Herd Effect

Overview

Journal Scand J Infect Dis

Publisher Informa Healthcare

Specialty Infectious Diseases

Date 2011 May 25

PMID 21604922

Citations 49

Authors

Tae Hyong Kim

Jennie Johnstone

Mark Loeb

Affiliations

Soon will be listed here.

Abstract

Vaccination ideally protects susceptible populations at high risk for complications of the infection. However, vaccines for these subgroups do not always provide sufficient effectiveness. The herd effect or herd immunity is an attractive way to extend vaccine benefits beyond the directly targeted population. It refers to the indirect protection of unvaccinated persons, whereby an increase in the prevalence of immunity by the vaccine prevents circulation of infectious agents in susceptible populations. The herd effect has had a major impact in the eradication of smallpox, has reduced transmission of pertussis, and protects against influenza and pneumococcal disease. A high uptake of vaccines is generally needed for success. In this paper we aim to provide an update review on the herd effect, focusing on the clinical benefit, by reviewing data for specific vaccines.

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References

Desai A, Grolleau-Julius A, Yung R . Leukocyte function in the aging immune system. J Leukoc Biol. 2010; 87(6):1001-9. PMC: 4057658. DOI: 10.1189/jlb.0809542. View

Smit P, OBERHOLZER D, HAYDEN-SMITH S, Koornhof H, HILLEMAN M . Protective efficacy of pneumococcal polysaccharide vaccines. JAMA. 1977; 238(24):2613-6. View

Hewlett E, Edwards K . Clinical practice. Pertussis--not just for kids. N Engl J Med. 2005; 352(12):1215-22. DOI: 10.1056/NEJMcp041025. View

Lynch 3rd J, Zhanel G . Streptococcus pneumoniae: epidemiology, risk factors, and strategies for prevention. Semin Respir Crit Care Med. 2009; 30(2):189-209. DOI: 10.1055/s-0029-1202938. View

Orozco M, Vasquez J, Pedreira C, De Oliveira L, Amador J, Malespin O . Uptake of rotavirus vaccine and national trends of acute gastroenteritis among children in Nicaragua. J Infect Dis. 2009; 200 Suppl 1:S125-30. DOI: 10.1086/605053. View

Monto A, DAVENPORT F, Napier J, FRANCIS Jr T . Modification of an outbreak of influenza in Tecumseh, Michigan by vaccination of schoolchildren. J Infect Dis. 1970; 122(1):16-25. DOI: 10.1093/infdis/122.1-2.16. View

Guris D, Strebel P, Bardenheier B, Brennan M, Tachdjian R, Finch E . Changing epidemiology of pertussis in the United States: increasing reported incidence among adolescents and adults, 1990-1996. Clin Infect Dis. 1999; 28(6):1230-7. DOI: 10.1086/514776. View

Van Effelterre T, Soriano-Gabarro M, Debrus S, Newbern E, Gray J . A mathematical model of the indirect effects of rotavirus vaccination. Epidemiol Infect. 2009; 138(6):884-97. DOI: 10.1017/S0950268809991245. View

Ramsay M, Andrews N, Trotter C, Kaczmarski E, Miller E . Herd immunity from meningococcal serogroup C conjugate vaccination in England: database analysis. BMJ. 2003; 326(7385):365-6. PMC: 148893. DOI: 10.1136/bmj.326.7385.365. View

10.

Poolman J, Lind I, Jonsdottir K, Froholm L, Jones D, Zanen H . Meningococcal serotypes and serogroup B disease in north-west Europe. Lancet. 1986; 2(8506):555-8. DOI: 10.1016/s0140-6736(86)90123-6. View

11.

Parashar U, Burton A, Lanata C, Boschi-Pinto C, Shibuya K, Steele D . Global mortality associated with rotavirus disease among children in 2004. J Infect Dis. 2009; 200 Suppl 1:S9-S15. DOI: 10.1086/605025. View

12.

Halloran M, Haber M, Longini Jr I, Struchiner C . Direct and indirect effects in vaccine efficacy and effectiveness. Am J Epidemiol. 1991; 133(4):323-31. DOI: 10.1093/oxfordjournals.aje.a115884. View

13.

Vesikari T, Matson D, Dennehy P, Van Damme P, Santosham M, Rodriguez Z . Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine. N Engl J Med. 2006; 354(1):23-33. DOI: 10.1056/NEJMoa052664. View

14.

Aguas R, Goncalves G, Gomes M . Pertussis: increasing disease as a consequence of reducing transmission. Lancet Infect Dis. 2006; 6(2):112-7. DOI: 10.1016/S1473-3099(06)70384-X. View

15.

Dasbach E, Elbasha E, Insinga R . Mathematical models for predicting the epidemiologic and economic impact of vaccination against human papillomavirus infection and disease. Epidemiol Rev. 2006; 28:88-100. DOI: 10.1093/epirev/mxj006. View

16.

. 23-valent pneumococcal polysaccharide vaccine. WHO position paper. Wkly Epidemiol Rec. 2008; 83(42):373-84. View

17.

Paavonen J, Naud P, Salmeron J, Wheeler C, Chow S, Apter D . Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women. Lancet. 2009; 374(9686):301-14. DOI: 10.1016/S0140-6736(09)61248-4. View

18.

Talbot T, Babcock H, Caplan A, Cotton D, Maragakis L, Poland G . Revised SHEA position paper: influenza vaccination of healthcare personnel. Infect Control Hosp Epidemiol. 2010; 31(10):987-95. DOI: 10.1086/656558. View

19.

Jefferson T, Rivetti D, Rivetti A, Rudin M, Di Pietrantonj C, Demicheli V . Efficacy and effectiveness of influenza vaccines in elderly people: a systematic review. Lancet. 2005; 366(9492):1165-74. DOI: 10.1016/S0140-6736(05)67339-4. View

20.

de Sanjose S, Diaz M, Castellsague X, Clifford G, Bruni L, Munoz N . Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. Lancet Infect Dis. 2007; 7(7):453-9. DOI: 10.1016/S1473-3099(07)70158-5. View