Association of Rheumatoid Arthritis Risk with EGFR Genetic Polymorphisms in Taiwan's Han Chinese Population

Overview

Journal Rheumatol Int

Specialty Rheumatology

Date 2011 May 24

PMID 21604062

Citations 10

Authors

Sui-Foon Lo

Lei Wan

Hsiu-Chen Lin

Chung-Ming Huang

Shih-Yin Chen

Su-Ching Liu

Fuu-Jen Tsai

Affiliations

Soon will be listed here.

Abstract

The involvement of the epidermal growth factor receptor (EGFR) in the pathogenesis of cancer is well documented. In contrast, its role in rheumatoid arthritis (RA) development is not that well defined although previous studies suggested the possible link between autoimmune diseases and malignancy. Therefore, we aimed to examine whether there is a link between the EGFR genetic polymorphisms and the RA. Our study gauged the effects of EGFR (rs11543848 and rs17337023) single-nucleotide polymorphisms (SNPs) on RA among Taiwan's Han Chinese population. Polymorphism of EGFR gene was analyzed in 188 RA patients and 128 control subjects. Genotyping for EGFR SNPs was performed by restriction fragment length polymorphism (RFLP) assay. Our data confirmed statistically significant increased risk of RA development in subjects with A carrier at rs17337023 SNP (P < 0.0001), and subjects with A allele at rs17337023 SNP (odds ratio [OR] = 1.52; 95% confidence interval [CI] = 1.10-2.09). Furthermore, comparison of haplotype frequencies between patients and controls suggested GA and AT haplotypes were more "at-risk" for RA development (P < 0.0001 and P < 0.01, respectively). However, comparisons of the clinical features of RA patients according to different genotypes and haplotypes revealed no significant difference. In conclusion, our data yield the new information on EGFR polymorphisms (rs11543848 and rs17337023) with the susceptibility of RA development and polymorphism revealed by this study merit further investigation.

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Rheumatoid arthritis is associated with rs17337023 polymorphism and increased serum level of the EGFR protein.

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