Integrins in Renal Development

Overview

Journal Pediatr Nephrol

Specialties Nephrology
Pediatrics

Date 2011 May 24

PMID 21603909

Citations 33

Authors

Sijo Mathew

Xiwu Chen

Ambra Pozzi

Roy Zent

Affiliations

Soon will be listed here.

Abstract

The kidney develops from direct interactions between the ureteric bud and the metanephric mesenchyme. The ureteric bud gives rise to the collecting system and the metanephric mesenchyme to the nephrons. The complex process of renal development which occurs between these embryologically distinct structures is mediated by numerous factors, including the communication of cells with their surrounding extracellular matrix. Integrins are the principal cellular receptors for extracellular matrix proteins, and they play a role in organ and tissue development. In this review we focus on how integrins regulate renal development.

Citing Articles

Integrins in the kidney - beyond the matrix.

Bock F, Li S, Pozzi A, Zent R Nat Rev Nephrol. 2024; 21(3):157-174.

PMID: 39643697 DOI: 10.1038/s41581-024-00906-1.

Integrin alpha1 beta1 promotes interstitial fibrosis in a mouse model of polycystic kidney disease.

Grenier C, Lin I, Peters D, Pozzi A, Lennon R, Naylor R bioRxiv. 2024; .

PMID: 39484448 PMC: 11526950. DOI: 10.1101/2024.10.18.619080.

The extracellular matrix protein fibronectin promotes metanephric kidney development.

Skoczynski K, Kraus A, Daniel C, Buttner-Herold M, Amann K, Schiffer M Pflugers Arch. 2024; 476(6):963-974.

PMID: 38563997 PMC: 11139724. DOI: 10.1007/s00424-024-02954-9.

Research progress on multiple cell death pathways of podocytes in diabetic kidney disease.

Yang C, Zhang Z, Liu J, Chen P, Li J, Shu H Mol Med. 2023; 29(1):135.

PMID: 37828444 PMC: 10571269. DOI: 10.1186/s10020-023-00732-4.

Modes of podocyte death in diabetic kidney disease: an update.

Jiang A, Song A, Zhang C J Nephrol. 2022; 35(6):1571-1584.

PMID: 35201595 DOI: 10.1007/s40620-022-01269-1.

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