Improving Donor Livers by Inhibiting TNF-α Production

Overview

Journal Ochsner J

Specialty General Medicine

Date 2011 May 24

PMID 21603393

Citations 3

Authors

Christopher P Zetzmann

O Rama Swamy

George E Loss Jr

Humberto Bohorquez

Ari J Cohen

Affiliations

Soon will be listed here.

Abstract

Hepatic ischemia/reperfusion (I/R) injury has a significant influence on the outcome of liver transplants. Inhibiting certain enzymatic reactions that occur during I/R injury may have a protective effect on the liver during transplantation. After reviewing the biochemical pathways involved in hepatic I/R injury, we describe a pharmacologic line of defense against this injury by means of the enzyme tissue inhibitor of metalloproteinase 3 (TIMP-3). Current results suggest that TIMP-3 will play a clinically relevant role in improving outcomes of liver transplants by reducing I/R injury to the donor liver.

Citing Articles

Paeoniflorin attenuates hepatic ischemia/reperfusion injury via anti-oxidative, anti-inflammatory and anti-apoptotic pathways.

Tao Y, Wen Z, Song Y, Wang H Exp Ther Med. 2016; 11(1):263-268.

PMID: 26889252 PMC: 4726947. DOI: 10.3892/etm.2015.2902.

Tumor Necrosis Factor-α: Life and Death of Hepatocytes During Liver Ischemia/Reperfusion Injury.

Shuh M, Bohorquez H, Loss Jr G, Cohen A Ochsner J. 2013; 13(1):119-30.

PMID: 23531747 PMC: 3603175.

The protective role of CD59 and pathogenic role of complement in hepatic ischemia and reperfusion injury.

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PMID: 22019898 PMC: 3260856. DOI: 10.1016/j.ajpath.2011.08.040.

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