Phospholipases a in Trypanosomatids

Overview

Journal Enzyme Res

Publisher Hindawi

Date 2011 May 24

PMID 21603263

Citations 10

Authors

Maria Laura Belaunzaran

Estela Maria Lammel

Elvira Luisa Durante de Isola

Affiliations

Soon will be listed here.

Abstract

Phospholipases are a complex and important group of enzymes widespread in nature, that play crucial roles in diverse biochemical processes and are classified as A(1), A(2), C, and D. Phospholipases A(1) and A(2) activities have been linked to pathogenesis in various microorganisms, and particularly in pathogenic protozoa they have been implicated in cell invasion. Kinetoplastids are a group of flagellated protozoa, including extra- and intracellular parasites that cause severe disease in humans and animals. In the present paper, we will mainly focus on the three most important kinetoplastid human pathogens, Trypanosoma brucei, Trypanosoma cruzi, and Leishmania spp., giving a perspective of the research done up to now regarding biochemical, biological, and molecular characteristics of Phospholipases A(1) and A(2) and their contribution to pathogenesis.

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