The Role of CT-Based Attenuation Correction and Collimator Blurring Correction in Striatal Spect Quantification

Overview

Journal Int J Mol Imaging

Date 2011 May 24

PMID 21603235

Citations 6

Authors

J M Warwick

S Rubow

M du Toit

E Beetge

P Carey

P Dupont

Affiliations

Soon will be listed here.

Abstract

Purpose. Striatal single photon emission computed tomography (SPECT) imaging of the dopaminergic system is becoming increasingly used for clinical and research studies. The question about the value of nonuniform attenuation correction has become more relevant with the increasing availability of hybrid SPECT-CT scanners. In this study, the value of nonuniform attenuation correction and correction for collimator blurring were determined using both phantom data and patient data. Methods. SPECT imaging was performed using 7 anthropomorphic phantom measurements, and 14 patient studies using [I-123]-FP-CIT (DATSCAN). SPECT reconstruction was performed using uniform and nonuniform attenuation correction and collimator blurring corrections. Recovery values (phantom data) or average-specific uptake ratios (patient data) for the different reconstructions were compared at similar noise levels. Results. For the phantom data, improved recovery was found with nonuniform attenuation correction and collimator blurring corrections, with further improvement when performed together. However, for patient data the highest average specific uptake ratio was obtained using collimator blurring correction without nonuniform attenuation correction, probably due to subtle SPECT-CT misregistration. Conclusions. This study suggests that an optimal brain SPECT reconstruction (in terms of the lowest bias) in patients would include a correction for collimator blurring and uniform attenuation correction.

Citing Articles

Attenuation and scatter correction in I-123 FP-CIT SPECT do not affect the clinical diagnosis of dopaminergic system neurodegeneration.

Akahoshi M, Abe K, Uchiyama Y, Momose M, Fukushima K, Kitagawa K Medicine (Baltimore). 2017; 96(45):e8484.

PMID: 29137036 PMC: 5690729. DOI: 10.1097/MD.0000000000008484.

CT-Based Attenuation Correction in Brain SPECT/CT Can Improve the Lesion Detectability of Voxel-Based Statistical Analyses.

Kato H, Shimosegawa E, Fujino K, Hatazawa J PLoS One. 2016; 11(7):e0159505.

PMID: 27442256 PMC: 4956081. DOI: 10.1371/journal.pone.0159505.

Influence of CT-based attenuation correction on dopamine transporter SPECT with [(123)I]FP-CIT.

Lapa C, Spehl T, Brumberg J, Isaias I, Schlogl S, Lassmann M Am J Nucl Med Mol Imaging. 2015; 5(3):278-86.

PMID: 26069861 PMC: 4446396.

The feasibility of using CT-guided ROI for semiquantifying striatal dopamine transporter availability in a hybrid SPECT/CT system.

Hsu C, Chang Y, Lin W, Tang S, Wang P, Huang Y ScientificWorldJournal. 2014; 2014:879497.

PMID: 25531005 PMC: 4233671. DOI: 10.1155/2014/879497.

CT-based attenuation correction in I-123-ioflupane SPECT.

Lange C, Seese A, Schwarzenbock S, Steinhoff K, Umland-Seidler B, Krause B PLoS One. 2014; 9(9):e108328.

PMID: 25268228 PMC: 4182457. DOI: 10.1371/journal.pone.0108328.

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