Gonadotropin-dependent Precocious Puberty: Neoplastic Causes and Endocrine Considerations

Overview

Journal Int J Pediatr Endocrinol

Publisher Biomed Central

Specialty Pediatrics

Date 2011 May 24

PMID 21603196

Citations 19

Authors

Matthew D Stephen

Peter E Zage

Steven G Waguespack

Affiliations

Soon will be listed here.

Abstract

Premature activation of the hypothalamic-pituitary-gonadal (HPG) axis manifests as gonadotropin-dependent precocious puberty. The mechanisms behind HPG activation are complex and a clear etiology for early activation is often not elucidated. Though collectively uncommon, the neoplastic and developmental causes of gonadotropin-dependent precocious puberty are very important to consider, as a delay in diagnosis may lead to adverse patient outcomes. The intent of the current paper is to review the neoplastic and developmental causes of gonadotropin-dependent precocious puberty. We discuss the common CNS lesions and human chorionic gonadotropin-secreting tumors that cause sexual precocity, review the relationship between therapeutic radiation and gonadotropin-dependent precocious puberty, and finally, provide an overview of the therapies available for height preservation in this unique patient population.

Citing Articles

Magnetic resonance imaging -based radiomics of the pituitary gland is highly predictive of precocious puberty in girls: a pilot study.

Maddalo M, Petraroli M, Ormitti F, Fulgoni A, Gnocchi M, Masetti M Front Endocrinol (Lausanne). 2025; 16:1496554.

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Inflammation and oxidative stress processes in induced precocious puberty in rats.

Pop R, Gherman L, Jianu E, Rosian S, Onofrei M, Mocan L Heliyon. 2025; 10(24):e40962.

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The Effect of GnRHa Treatment on Body Mass Index in Central Precocious Puberty: A Systematic Review and Meta-Analysis.

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Congenital Portosystemic Shunts: Variable Clinical Presentations Requiring a Tailored Endovascular or Surgical Approach.

Bent Robinson E, Jordan G, Katz D, Sundaram S, Boster J, Brigham D JPGN Rep. 2023; 4(1):e279.

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Rapidly Progressive Precocious Puberty With an Elevated Testosterone Level in a 5-Year-Old Boy With a β-Human Chorionic Gonadotropin-Secreting Intracranial Germ Cell Tumor in the Pineal Gland.

Parra Villasmil M, Kim C, Sato M, Kanner L AACE Clin Case Rep. 2022; 8(4):174-178.

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