NADPH Oxidases in Cardiovascular Disease: Insights from in Vivo Models and Clinical Studies

Overview

Journal Basic Res Cardiol

Specialty Cardiology & Vascular Diseases

Date 2011 May 21

PMID 21598086

Citations 97

Authors

Alexander Sirker

Min Zhang

Ajay M Shah

Affiliations

Soon will be listed here.

Abstract

NADPH oxidase family enzymes (or NOXs) are the major sources of reactive oxygen species (ROS) that are implicated in the pathophysiology of many cardiovascular diseases. These enzymes appear to be especially important in the modulation of redox-sensitive signalling pathways that underlie key cellular functions such as growth, differentiation, migration and proliferation. Seven distinct members of the family have been identified of which four (namely NOX1, 2, 4 and 5) may have cardiovascular functions. In this article, we review our current understanding of the roles of NOX enzymes in several common cardiovascular disease states, with a focus on data from genetic studies and clinical data where available.

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