Alpha T-catenin (CTNNA3): a Gene in the Hand is Worth Two in the Nest

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2011 May 21

PMID 21598020

Citations 9

Authors

James D Smith

Maria H Meehan

John Crean

Amanda McCann

Affiliations

Soon will be listed here.

Abstract

Alpha-T-Catenin (CTNNA3) is a key protein of the adherens junctional complex in epithelial cells playing a crucial role in cellular adherence. What makes this gene particularly interesting is that it is located within a common fragile site, is epigenetically regulated, is transcribed through multiple promoters, and generates a variety of alternate transcripts. Finally, CTNNA3 has a nested gene (LRTMM3) embedded within its genomic context transcribed in the opposite direction. Apart from the complexity of its regulation, alterations in both CTNNA3 and LRTMM3 are implicated in human disease.

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