Abnormalities in the Enamel in Bmp2-deficient Mice

Overview

Journal Cells Tissues Organs

Publisher Karger

Specialties Anatomy & Histology
Cell Biology

Date 2011 May 21

PMID 21597270

Citations 23

Authors

Junsheng Feng

Guobin Yang

Guohua Yuan

Jelica Gluhak-Heinrich

Wuchen Yang

Lynn Wang

Zhi Chen

Jennifer Schulze McDaniel

Kevin J Donly

Stephen E Harris

Mary Macdougall

Shuo Chen

Affiliations

Soon will be listed here.

Abstract

Tooth development is regulated by epithelial-mesenchymal interactions and their reciprocal molecular signaling. Bone morphogenetic protein 2 (Bmp2) is essential for tooth formation. However, the role of Bmp2 during enamel formation remains unknown in vivo. In this study, the role of Bmp2 in the regulation of postnatal enamel formation was investigated via the conditional ablation of Bmp2 in enamel using the (Osx-Cre) mouse. Bmp2 gene ablation was confirmed by PCR analysis in Osx-Cre, Bmp2(flox/flox) mice. Bmp2-null mice displayed a severe and profound tooth phenotype with asymmetric and open forked incisors. Microradiographs revealed broken incisor tips and dental pulp chamber exposure. The enamel layer of incisors and molars was thin with hypomineralization. Scanning electron microscopy analysis showed that the enamel surface was rough with chipping and the enamel lacked a typical prismatic architecture. These results demonstrate that Bmp2 is essential for enamel formation.

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