Evaluation of the Microbicidal Activity and Cytokines/chemokines Profile Released by Neutrophils from HTLV-1-infected Individuals

Overview

Journal Scand J Immunol

Specialty Allergy & Immunology

Date 2011 May 21

PMID 21595736

Citations 6

Authors

Caroline A Bezerra

Thiago M Cardoso

Angela Giudice

Aurelia F Porto

Silvane B Santos

Edgar M Carvalho

Olivia Bacellar

Affiliations

Soon will be listed here.

Abstract

Human T cell lymphotropic virus type-1 (HTLV-1) induces activation and spontaneous proliferation of T cells with production of type-1 pro-inflammatory cytokines. It modifies the immune response to other antigens and increases susceptibility to infectious diseases. However, little is known about innate immunity in HTLV-1 infection. HTLV-1-infected individuals have higher spontaneous neutrophil activation than HTLV-1-seronegative individuals, as shown by the nitroblue tetrazolium (NBT) assay. This study was conducted to evaluate neutrophil function in HTLV-1-infected individuals. Participants in the study included 18 HTLV-1-infected individuals and 14 HTLV-1-seronegative controls. We evaluated the ability of neutrophils (PMNs) to control a parasite infection, to produce peroxynitrite, cytokines and chemokines and to express activation markers in cultures when stimulated with LPS or infected with Leishmania. When compared with the control group, there was no difference in the percentage of PMNs infected with Leishmania or in the number of amastigotes/100 PMNs in HTLV-1-infected individuals. The microbicidal activity of the PMNs and the levels of CXCL8 and CCL4 released by these cells did not show a difference between HTLV-1-infected individuals and the control group. In both the HTLV-1 group and the control group, infection with Leishmania or stimulation of PMNs led to cellular activation. These observations suggest that neutrophils from HTLV-1-infected individuals have preserved their ability to become activated and to produce chemokines and peroxynitrite after stimulation and that the susceptibility to infection by intracellular Leishmania amazonensis in HTLV-1-infected individuals does not depend on impairment of neutrophil function.

Citing Articles

Immunopathogenesis and Cellular Interactions in Human T-Cell Leukemia Virus Type 1 Associated Myelopathy/Tropical Spastic Paraparesis.

Aghajanian S, Teymoori-Rad M, Molaverdi G, Mozhgani S Front Microbiol. 2021; 11:614940.

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The Role of Chemokines in the Pathogenesis of HTLV-1.

Zargari R, Mahdifar M, Mohammadi A, Vahidi Z, Hassanshahi G, Rafatpanah H Front Microbiol. 2020; 11:421.

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Characterization of Neutrophil Function in Human Cutaneous Leishmaniasis Caused by Leishmania braziliensis.

Conceicao J, Davis R, Carneiro P, Giudice A, Muniz A, Wilson M PLoS Negl Trop Dis. 2016; 10(5):e0004715.

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Neutrophil-derived chemokines on the road to immunity.

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Functional activity of monocytes and macrophages in HTLV-1 infected subjects.

Amorim C, Souza A, Diniz A, Carvalho N, Santos S, Carvalho E PLoS Negl Trop Dis. 2014; 8(12):e3399.

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