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Recent Advances of Chitosan Nanoparticles As Drug Carriers

Overview
Publisher Dove Medical Press
Specialty Biotechnology
Date 2011 May 19
PMID 21589644
Citations 172
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Abstract

Chitosan nanoparticles are good drug carriers because of their good biocompatibility and biodegradability, and can be readily modified. As a new drug delivery system, they have attracted increasing attention for their wide applications in, for example, loading protein drugs, gene drugs, and anticancer chemical drugs, and via various routes of administration including oral, nasal, intravenous, and ocular. This paper reviews published research on chitosan nanoparticles, including its preparation methods, characteristics, modification, in vivo metabolic processes, and applications.

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References
1.
Liu X . [Chitosan-siRNA complex nanoparticles for gene silencing]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2010; 27(1):97-101. View

2.
Katas H, Alpar H . Development and characterisation of chitosan nanoparticles for siRNA delivery. J Control Release. 2006; 115(2):216-25. DOI: 10.1016/j.jconrel.2006.07.021. View

3.
Amidi M, Mastrobattista E, Jiskoot W, Hennink W . Chitosan-based delivery systems for protein therapeutics and antigens. Adv Drug Deliv Rev. 2009; 62(1):59-82. DOI: 10.1016/j.addr.2009.11.009. View

4.
Yin L, Ding J, He C, Cui L, Tang C, Yin C . Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery. Biomaterials. 2009; 30(29):5691-700. DOI: 10.1016/j.biomaterials.2009.06.055. View

5.
Bodnar M, Hartmann J, Borbely J . Preparation and characterization of chitosan-based nanoparticles. Biomacromolecules. 2005; 6(5):2521-7. DOI: 10.1021/bm0502258. View