Is There a Role for Fluorine 18 Fluorodeoxyglucose-positron Emission Tomography and Positron Emission Tomography/computed Tomography in Evaluating Patients with Mycobacteriosis? A Systematic Review

Overview

Journal J Comput Assist Tomogr

Specialty Radiology

Date 2011 May 19

PMID 21586936

Citations 13

Authors

Giorgio Treglia

Silvia Taralli

Maria Lucia Calcagni

Fabio Maggi

Alessandro Giordano

Lorenzo Bonomo

Affiliations

Soon will be listed here.

Abstract

Objective: This study was designed to review the emerging role of fluorine 18 fluorodeoxyglucose (¹⁸F-FDG)-positron emission tomography (PET) CT/computed tomography (PET/CT) in patients with mycobacteriosis.

Methods: A comprehensive literature search of published studies through October 2010 in PubMed/MEDLINE database regarding ¹⁸F-FDG-PET and PET/CT in patients with mycobacteriosis was performed.

Results: Ultimately, we identified 16 studies comprising a total of 220 patients with mycobacteriosis. Main findings of the included studies are presented.

Conclusions: (1) Mycobacteriosis commonly causes increased ¹⁸F-FDG uptake; therefore, positive ¹⁸F-FDG-PET results should be interpreted with caution in differentiating benign from malignant abnormalities. (2) ¹⁸F-FDG-PET and PET/CT are potentially useful in detecting sites of Mycobacterium infection. (3) Dual-phase ¹⁸F-FDG-PET is not useful for the differential diagnosis between malignant lesions and sites of Mycobacterium infection. (4) ¹⁸F-FDG-PET and PET/CT are useful for the evaluation of disease activity and in monitoring response to therapy in patients with mycobacteriosis. (5) Dual-tracer PET and PET/CT are potentially useful for presumptive diagnosis of solitary pulmonary nodules.

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