The Impact of Caveolin Protein Expression in Tumor Stroma on Prognosis of Breast Cancer

Overview

Journal Tumour Biol

Publisher Sage Publications

Specialty Oncology

Date 2011 May 18

PMID 21584795

Citations 34

Authors

Ja Seung Koo

Seho Park

Seung Il Kim

Sarah Lee

Byeong-Woo Park

Affiliations

Soon will be listed here.

Abstract

We aimed to investigate the expression of caveolin-1, -2, -3, and platelet-derived growth factor (PDGF) β receptor in breast cancer cells and stroma by immunohistochemistry and to analyze their implications. The expression rates of stromal caveolin-2 and PDGF β receptor increased as the tumor progressed from ductal carcinoma in situ to microinvasive ductal carcinoma, intraductal component of invasive ductal carcinoma (IDC), and IDC (p<0.001). The expression loss of caveolin-1 in tumor stroma of IDC correlated with high tumor stage (p<0.001), high nodal stage (p=0.011), high cancer stage (p=0.005), estrogen receptor negativity (p=0.003), and tumor recurrence (p=0.003). In addition, the expression loss of caveolin-1 in tumor stroma was correlated with a shorter disease-free survival and an overall survival (p<0.001). In conclusion, the loss of stromal caveolin-1 is related to poor prognosis in IDC.

Citing Articles

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Role of Caveolae family-related proteins in the development of breast cancer.

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Wang S, Chang X, Zhang J, Li J, Wang N, Yang B Front Oncol. 2021; 11:745584.

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Stromal Caveolin-1 and Caveolin-2 Expression in Primary Tumors and Lymph Node Metastases.

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