Expression of Locus Coeruleus Mineralocorticoid Receptor and Glucocorticoid Receptor in Rats Under Single-prolonged Stress

Overview

Journal Neurol Sci

Specialty Neurology

Date 2011 May 18

PMID 21584742

Citations 11

Authors

Man Li

Fang Han

Yuxiu Shi

Affiliations

Soon will be listed here.

Abstract

The pathogenesis of the post-traumatic stress disorder (PTSD) may involve dysfunction of several brain structures, such as the amygdala, locus coeruleus, hippocampus, noradrenergic system as well as the hypothalamic-pituitary-adrenal (HPA) axis. The cortisol and locus coeruleus dysfunction may affect the secretion of corticosterone. The present study was designed to examine the expression of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) in the locus coeruleus in the rats treated with single-prolonged stress (SPS). The results showed that the expression of MR had a sharp decline on day 1, but gradually increased on days 4, 7, 14, and 28. The expression of GR gradually increased on days 1, 4, and 7, but decreased on days 14 and 28, respectively.MR and GR in the locus coeruleus may have a role in the development of long-term persistent neuropsychological sequelae in PTSD.

Citing Articles

Transcriptome profiles associated with resilience and susceptibility to single prolonged stress in the locus coeruleus and nucleus accumbens in male sprague-dawley rats.

Nahvi R, Tanelian A, Nwokafor C, Godino A, Parise E, Estill M Behav Brain Res. 2022; 439:114162.

PMID: 36257560 PMC: 9812303. DOI: 10.1016/j.bbr.2022.114162.

Rat models for low and high adaptive response to exercise differ for stress-related memory and anxiety.

Vanderheyden W, Kehoe M, Vanini G, Britton S, Koch L Physiol Rep. 2021; 9(4):e14716.

PMID: 33619911 PMC: 7900769. DOI: 10.14814/phy2.14716.

Chronic Sleep Disruption Potentiates Locus Ceruleus Tauopathy in a Mouse Model of Alzheimer's Disease.

Spiers J, Chen H J Neurosci. 2019; 39(25):4844-4846.

PMID: 31217341 PMC: 6670251. DOI: 10.1523/JNEUROSCI.3265-18.2019.

Corticosterone Upregulates Gene and Protein Expression of Catecholamine Markers in Organotypic Brainstem Cultures.

Busceti C, Ferese R, Bucci D, Ryskalin L, Gambardella S, Madonna M Int J Mol Sci. 2019; 20(12).

PMID: 31197099 PMC: 6627138. DOI: 10.3390/ijms20122901.

Single-Prolonged Stress: A Review of Two Decades of Progress in a Rodent Model of Post-traumatic Stress Disorder.

Lisieski M, Eagle A, Conti A, Liberzon I, Perrine S Front Psychiatry. 2018; 9:196.

PMID: 29867615 PMC: 5962709. DOI: 10.3389/fpsyt.2018.00196.

References

Foa E, Zinbarg R, Rothbaum B . Uncontrollability and unpredictability in post-traumatic stress disorder: an animal model. Psychol Bull. 1992; 112(2):218-38. DOI: 10.1037/0033-2909.112.2.218. View

Wang W, Liu Y, Zheng H, Wang H, Jin X, Chen Y . A modified single-prolonged stress model for post-traumatic stress disorder. Neurosci Lett. 2008; 441(2):237-41. DOI: 10.1016/j.neulet.2008.06.031. View

Jobson L . Drawing current posttraumatic stress disorder models into the cultural sphere: the development of the 'threat to the conceptual self' model. Clin Psychol Rev. 2009; 29(4):368-81. DOI: 10.1016/j.cpr.2009.03.002. View

Blaeser F, Sanders M, Truong N, Ko S, Wu L, Wozniak D . Long-term memory deficits in Pavlovian fear conditioning in Ca2+/calmodulin kinase kinase alpha-deficient mice. Mol Cell Biol. 2006; 26(23):9105-15. PMC: 1636841. DOI: 10.1128/MCB.01452-06. View

Oitzl M, Van Haarst A, Sutanto W, de Kloet E . Corticosterone, brain mineralocorticoid receptors (MRs) and the activity of the hypothalamic-pituitary-adrenal (HPA) axis: the Lewis rat as an example of increased central MR capacity and a hyporesponsive HPA axis. Psychoneuroendocrinology. 1995; 20(6):655-75. DOI: 10.1016/0306-4530(95)00003-7. View

Rasmusson A, Vythilingam M, Morgan 3rd C . The neuroendocrinology of posttraumatic stress disorder: new directions. CNS Spectr. 2004; 8(9):651-6, 665-7. DOI: 10.1017/s1092852900008841. View

Zhe D, Fang H, Yuxiu S . Expressions of hippocampal mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) in the single-prolonged stress-rats. Acta Histochem Cytochem. 2008; 41(4):89-95. PMC: 2532603. DOI: 10.1267/ahc.08013. View

Stein M, Yehuda R, Koverola C, Hanna C . Enhanced dexamethasone suppression of plasma cortisol in adult women traumatized by childhood sexual abuse. Biol Psychiatry. 1997; 42(8):680-6. DOI: 10.1016/s0006-3223(96)00489-1. View

Liberzon I, Lopez J, Flagel S, Vazquez D, Young E . Differential regulation of hippocampal glucocorticoid receptors mRNA and fast feedback: relevance to post-traumatic stress disorder. J Neuroendocrinol. 1999; 11(1):11-7. DOI: 10.1046/j.1365-2826.1999.00288.x. View

10.

Handwerger K . Differential patterns of HPA activity and reactivity in adult posttraumatic stress disorder and major depressive disorder. Harv Rev Psychiatry. 2009; 17(3):184-205. DOI: 10.1080/10673220902996775. View

11.

Dickstein B, Suvak M, Litz B, Adler A . Heterogeneity in the course of posttraumatic stress disorder: trajectories of symptomatology. J Trauma Stress. 2010; 23(3):331-9. DOI: 10.1002/jts.20523. View

12.

Gass P, Reichardt H, Strekalova T, Henn F, Tronche F . Mice with targeted mutations of glucocorticoid and mineralocorticoid receptors: models for depression and anxiety?. Physiol Behav. 2001; 73(5):811-25. DOI: 10.1016/s0031-9384(01)00518-2. View

13.

Kimble M, Kaufman M . Clinical correlates of neurological change in posttraumatic stress disorder: an overview of critical systems. Psychiatr Clin North Am. 2004; 27(1):49-65, viii. DOI: 10.1016/S0193-953X(03)00108-4. View

14.

Ehlert U, Wagner D, Heinrichs M, Heim C . [Psychobiological aspects of posttraumatic stress disorder]. Nervenarzt. 1999; 70(9):773-9. DOI: 10.1007/s001150050511. View

15.

Witteveen A, Huizink A, Slottje P, Bramsen I, Smid T, van der Ploeg H . Associations of cortisol with posttraumatic stress symptoms and negative life events: a study of police officers and firefighters. Psychoneuroendocrinology. 2010; 35(7):1113-8. DOI: 10.1016/j.psyneuen.2009.12.013. View

16.

Dikanovic M, Kadojic D, Demarin V, Trkanjec Z, Mihaljevic I, Bitunjac M . The effect of stress hormones on cerebral hemodynamics in patients with chronic posttraumatic stress disorder. Acta Clin Croat. 2010; 48(4):405-11. View

17.

Cohen H, Matar M, Buskila D, Kaplan Z, Zohar J . Early post-stressor intervention with high-dose corticosterone attenuates posttraumatic stress response in an animal model of posttraumatic stress disorder. Biol Psychiatry. 2008; 64(8):708-717. DOI: 10.1016/j.biopsych.2008.05.025. View

18.

Cui H, Sakamoto H, Higashi S, Kawata M . Effects of single-prolonged stress on neurons and their afferent inputs in the amygdala. Neuroscience. 2008; 152(3):703-12. DOI: 10.1016/j.neuroscience.2007.12.028. View

19.

Adamec R, Muir C, Grimes M, Pearcey K . Involvement of noradrenergic and corticoid receptors in the consolidation of the lasting anxiogenic effects of predator stress. Behav Brain Res. 2007; 179(2):192-207. DOI: 10.1016/j.bbr.2007.02.001. View

20.

Kozlovsky N, Matar M, Kaplan Z, Zohar J, Cohen H . A distinct pattern of intracellular glucocorticoid-related responses is associated with extreme behavioral response to stress in an animal model of post-traumatic stress disorder. Eur Neuropsychopharmacol. 2009; 19(11):759-71. DOI: 10.1016/j.euroneuro.2009.04.009. View