» Articles » PMID: 21584269

Effect of the Japanese Herbal Kampo Medicine Dai-kenchu-to on Postoperative Adhesive Small Bowel Obstruction Requiring Long-tube Decompression: a Propensity Score Analysis

Overview
Date 2011 May 18
PMID 21584269
Citations 19
Authors
Affiliations
Soon will be listed here.
Abstract

Adhesive small bowel obstruction (ASBO) is an adverse consequence of abdominal surgery. Although the Kampo medicine Dai-kenchu-to is widely used in Japan for treatment of postoperative ASBO, rigorous clinical studies for its use have not been performed. In the present retrospective observational study using the Japanese diagnosis procedure combination inpatient database, we selected 288 propensity-score-matched patients with early postoperative ASBO following colorectal cancer surgery, who received long-tube decompression (LTD) with or without Dai-kenchu-to administration. The success rates of LTD were not significantly different between Dai-kenchu-to users and nonusers (84.7% versus 78.5%; P = .224), while Dai-kenchu-to users showed a shorter duration of LTD (8 versus 10 days; P = .012), shorter duration between long-tube insertion and discharge (23 versus 25 days; P = .018), and lower hospital charges ($23,086 versus $26,950; P = .018) compared with Dai-kenchu-to nonusers. In conclusion, the present study suggests that Dai-kenchu-to is effective for reducing the duration of LTD and saving costs.

Citing Articles

The Integration of Traditional Medicine with Conventional Biomedicine: A Narrative Review of the Japanese Perspective.

Yoshino T, Kashio A, Terasawa Y, Hachiki M, Yoshinaga R, Arita R J Integr Complement Med. 2023; 29(6-7):372-379.

PMID: 36961400 PMC: 10280171. DOI: 10.1089/jicm.2022.0643.


Efficacy of Daikenchuto in the prevention of bowel obstruction in patients with colorectal cancer undergoing laparoscopic surgery: An observational study using a Japanese administrative claims database.

Kunitomi Y, Nakashima M, Takeuchi M, Kawakami K Support Care Cancer. 2023; 31(2):133.

PMID: 36697914 DOI: 10.1007/s00520-023-07599-5.


Kampo Medicine for Various Aging-Related Symptoms: A Review of Geriatric Syndrome.

Takayama S, Tomita N, Arita R, Ono R, Kikuchi A, Ishii T Front Nutr. 2020; 7:86.

PMID: 32766269 PMC: 7381143. DOI: 10.3389/fnut.2020.00086.


Outpatient Prescriptions of Kampo Formulations in Japan.

Yamana H, Ono S, Michihata N, Jo T, Yasunaga H Intern Med. 2020; 59(22):2863-2869.

PMID: 32713918 PMC: 7725628. DOI: 10.2169/internalmedicine.5012-20.


Characteristics and course of patients treated with Kampo Medicine in the Department of General Medicine.

Takayama S, Akaishi T, Nozaki H, Suzuki S, Arita R, Saito N J Gen Fam Med. 2020; 21(3):48-55.

PMID: 32489756 PMC: 7260161. DOI: 10.1002/jgf2.294.


References
1.
Suehiro T, Matsumata T, Shikada Y, Sugimachi K . The effect of the herbal medicines dai-kenchu-to and keishi-bukuryo-gan on bowel movement after colorectal surgery. Hepatogastroenterology. 2005; 52(61):97-100. View

2.
Iyer S, Saunders W, Stemkowski S . Economic burden of postoperative ileus associated with colectomy in the United States. J Manag Care Pharm. 2009; 15(6):485-94. PMC: 10438346. DOI: 10.18553/jmcp.2009.15.6.485. View

3.
Yoshikawa K, Kurita N, Higashijima J, Miyatani T, Miyamoto H, Nishioka M . Kampo medicine "Dai-kenchu-to" prevents bacterial translocation in rats. Dig Dis Sci. 2008; 53(7):1824-31. DOI: 10.1007/s10620-008-0281-3. View

4.
Kono T, Kanematsu T, Kitajima M . Exodus of Kampo, traditional Japanese medicine, from the complementary and alternative medicines: is it time yet?. Surgery. 2009; 146(5):837-40. DOI: 10.1016/j.surg.2009.06.012. View

5.
Sato Y, Katagiri F, Inoue S, Itoh H, Takeyama M . Dai-kenchu-to raises levels of calcitonin gene-related peptide and substance P in human plasma. Biol Pharm Bull. 2004; 27(11):1875-7. DOI: 10.1248/bpb.27.1875. View