Viral Antibodies in Blood in Obsessive Compulsive Disorder

Overview

Journal Indian J Psychiatry

Specialty Psychiatry

Date 2011 May 18

PMID 21584073

Citations 6

Authors

S Khanna

V Ravi

P K Shenoy

A Chandramukhi

S M Channabasavanna

Affiliations

Soon will be listed here.

Abstract

IgG viral antibodies for herpes simplex virus -1, varicella zoster virus, cytomegalovirus, measles and mumps were studied in 76 subjects with obsessive compulsive disorder and compared with a control population. There was a significantly higher titre for some of the antibodies, most specifically for herpes simplex virus type 1 and mumps. This suggests a possible role for these viral infections in the pathogenesis of obsessive compulsive disorder.

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References

Khanna S . Obsessive-compulsive disorder: is there a frontal lobe dysfunction?. Biol Psychiatry. 1988; 24(5):602-13. DOI: 10.1016/0006-3223(88)90171-0. View

Jenike M . Obsessive-compulsive disorder: a question of a neurologic lesion. Compr Psychiatry. 1984; 25(3):298-304. DOI: 10.1016/0010-440x(84)90062-2. View

Swedo S, Rapoport J, Cheslow D, Leonard H, Ayoub E, HOSIER D . High prevalence of obsessive-compulsive symptoms in patients with Sydenham's chorea. Am J Psychiatry. 1989; 146(2):246-9. DOI: 10.1176/ajp.146.2.246. View

Mahalingam R, Wellish M, Wolf W, Dueland A, Cohrs R, Vafai A . Latent varicella-zoster viral DNA in human trigeminal and thoracic ganglia. N Engl J Med. 1990; 323(10):627-31. DOI: 10.1056/NEJM199009063231002. View

Cooper J . The Leyton obsessional inventory. Psychol Med. 1970; 1(1):48-64. DOI: 10.1017/s0033291700040010. View

Khanna S, Rajendra P, Channabasavanna S . Life events and onset of obsessive compulsive disorder. Int J Soc Psychiatry. 1988; 34(4):305-9. DOI: 10.1177/002076408803400408. View

Hossain A . Herpes simplex virus type 1 (HSV-1) and varicella-zoster virus (VZV) infections in Saudi Arabia. J Trop Pediatr. 1989; 35(4):171-4. DOI: 10.1093/tropej/35.4.171. View

Barton R . Diabetes insipidus and obsessional neurosis. A syndrome. Lancet. 1965; 1(7377):133-5. DOI: 10.1016/s0140-6736(65)91092-5. View

Insel T, Mueller E, Alterman I, Linnoila M, Murphy D . Obsessive-compulsive disorder and serotonin: is there a connection?. Biol Psychiatry. 1985; 20(11):1174-88. DOI: 10.1016/0006-3223(85)90176-3. View

10.

Zohar J, Mueller E, Insel T, Murphy D . Serotonergic responsivity in obsessive-compulsive disorder. Comparison of patients and healthy controls. Arch Gen Psychiatry. 1987; 44(11):946-51. DOI: 10.1001/archpsyc.1987.01800230026006. View

11.

Insel T . Obsessive-compulsive disorder: a neuroethological perspective. Psychopharmacol Bull. 1988; 24(3):365-9. View

12.

Rapoport J, Wise S . Obsessive-compulsive disorder: evidence for basal ganglia dysfunction. Psychopharmacol Bull. 1988; 24(3):380-4. View

13.

Damasio A, Van Hoesen G . The limbic system and the localisation of herpes simplex encephalitis. J Neurol Neurosurg Psychiatry. 1985; 48(4):297-301. PMC: 1028292. DOI: 10.1136/jnnp.48.4.297. View

14.

Grimshaw L . OBSESSIONAL DISORDER AND NEUROLOGICAL ILLNESS. J Neurol Neurosurg Psychiatry. 1964; 27:229-31. PMC: 495730. DOI: 10.1136/jnnp.27.3.229. View

15.

Wilson L . Viral encephalopathy mimicking functional psychosis. Am J Psychiatry. 1976; 133(2):165-70. DOI: 10.1176/ajp.133.2.165. View

16.

Abbey S, Garfinkel P . Chronic fatigue syndrome and the psychiatrist. Can J Psychiatry. 1990; 35(7):625-33. DOI: 10.1177/070674379003500714. View

17.

Hamilton M . A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960; 23:56-62. PMC: 495331. DOI: 10.1136/jnnp.23.1.56. View

18.

Altshuler L, Casanova M, Goldberg T, Kleinman J . The hippocampus and parahippocampus in schizophrenia, suicide, and control brains. Arch Gen Psychiatry. 1990; 47(11):1029-34. DOI: 10.1001/archpsyc.1990.01810230045008. View

19.

Davis L, Johnson R . An explanation for the localization of herpes simplex encephalitis?. Ann Neurol. 1979; 5(1):2-5. DOI: 10.1002/ana.410050103. View

20.

Drachman D, Adams R . Herpes simplex and acute inclusion-body encephalitis. Arch Neurol. 1962; 7:45-63. DOI: 10.1001/archneur.1962.04210010051005. View