Heterotypic Protection Induced by Synthetic Peptides Corresponding to Three Serotypes of Foot-and-mouth Disease Virus

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1990 May 1

PMID 2157884

Citations 11

Authors

T R Doel

C Gale

C M do Amaral

G Mulcahy

R DiMarchi

Affiliations

Soon will be listed here.

Abstract

Synthetic peptide vaccines of the general sequence Cys-Cys(200-213)-Pro-Pro-Ser-(141-158)-Pro-Cys-Gly, where the numbered residues refer to VP1 sequences of three different strains of foot-and-mouth disease virus, have been evaluated in cattle and guinea pigs. High levels of serotype-specific (homotypic) antiviral and antipeptide antibody were produced with each peptide. The A- and O-serotype peptides provided complete protection of guinea pigs against their respective virus challenges. The C-serotype peptide appeared to be less effective than the other peptides. In cross-protection studies (heterotypic) in guinea pigs, it was possible to protect A-serotype peptide-vaccinated animals against O-virus challenge and vice versa. Some heterotypic protection was also achieved with the C-serotype peptide. The heterotypic protection observed related more to the presence of cross-reactive antipeptide antibody than to neutralizing antibody.

Citing Articles

Promising multiple-epitope recombinant vaccine against foot-and-mouth disease virus type O in swine.

Shao J, Wong C, Lin T, Lee S, Cong G, Sin F Clin Vaccine Immunol. 2010; 18(1):143-9.

PMID: 21084463 PMC: 3019777. DOI: 10.1128/CVI.00236-10.

Intranasal immunization of guinea pigs with an immunodominant foot-and-mouth disease virus peptide conjugate induces mucosal and humoral antibodies and protection against challenge.

Fischer D, Rood D, Barrette R, Zuwallack A, Kramer E, Brown F J Virol. 2003; 77(13):7486-91.

PMID: 12805448 PMC: 164810. DOI: 10.1128/jvi.77.13.7486-7491.2003.

A large-scale evaluation of peptide vaccines against foot-and-mouth disease: lack of solid protection in cattle and isolation of escape mutants.

Taboga O, Tami C, Carrillo E, Nunez J, Rodriguez A, Saiz J J Virol. 1997; 71(4):2606-14.

PMID: 9060612 PMC: 191381. DOI: 10.1128/JVI.71.4.2606-2614.1997.

First peptide vaccine providing protection against viral infection in the target animal: studies of canine parvovirus in dogs.

Langeveld J, Casal J, Osterhaus A, Cortes E, De Swart R, Vela C J Virol. 1994; 68(7):4506-13.

PMID: 8207825 PMC: 236377. DOI: 10.1128/JVI.68.7.4506-4513.1994.

Antigenic heterogeneity of a foot-and-mouth disease virus serotype in the field is mediated by very limited sequence variation at several antigenic sites.

Mateu M, Hernandez J, Martinez M, Feigelstock D, Lea S, Perez J J Virol. 1994; 68(3):1407-17.

PMID: 8107204 PMC: 236594. DOI: 10.1128/JVI.68.3.1407-1417.1994.

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