[Affection of Central Nervous System in Hemorrhagic Fever with Renal Syndrome]

The authors report results of comparative analysis of 897 cases of hemorrhagic fever with renal syndrome diagnosed in the Upper Amur region in 1960-2005. All the patients were grouped by 5-year intervals depending on the severity of clinical condition. The frequency of CNS affection accompanied by acute psychic disorders, convulsive and meningeal syndromes varied significantly in different years. Pituitary hemorrhage was revealed at autopsy in 36.8% of the patients, pituitary necrosis in 5.2%, brainstem hemorrhage in 68.4%. A case of severe hemorrhagic fever with renal syndrome is described characterized by acute renal insufficiency and eclamptic convulsions with moderately manifest hemorrhagic syndrome preceding the favourable outcome.