Male Gender is a Risk Factor for Recurrent Appendicitis Following Nonoperative Treatment

Overview

Journal World J Surg

Publisher Wiley

Specialty General Surgery

Date 2011 May 17

PMID 21573957

Citations 5

Authors

Wan-Ching Lien

Wen-Chung Lee

Hsiu-Po Wang

Yi-Chu Chen

Kao-Lang Liu

Chien-Jen Chen

Affiliations

Soon will be listed here.

Abstract

Background: This prospective study investigates recurrence rates and identifies predictive factors for recurrence following successful nonoperative treatment in adult patients with acute appendicitis.

Methods: Between January 2003 and December 2009, adult patients with acute appendicitis who received successful nonoperative management were enrolled. Cumulative recurrence rates were calculated using the Kaplan-Meier method. Recurrence-free curves were compared using with the log-rank test. Cox regression models were employed to identify parameters that significantly and independently predict recurrence.

Results: During the study period, 128 patients were enrolled. The median follow-up period was 12 months (range=1-90 months). Twenty (16%) patients developed recurrent appendicitis during follow-up. Twenty-one (16%) patients underwent interval appendectomy (IA). There was no significant difference between nonperforated (NPA) and perforated appendicitis (PA) groups with respect to recurrence rates (16% at the 9th month). Moreover, male gender was significantly associated with recurrence (HR 3.45; 95% CI, 1.15-10.39). Analytical results remained significant after excluding IA patients.

Conclusions: Since the recurrence rate is similar between NPA and PA, nonoperative treatment can be used for PA patients. Roughly 20% of the adult patients selected for nonoperative treatment experienced recurrence. Males were more susceptible than females to recurrent appendicitis.

Citing Articles

Sex Differences in Appendicitis: A Systematic Review.

Kollias T, Gallagher C, Albaashiki A, Burle V, Slouha E Cureus. 2024; 16(5):e60055.

PMID: 38854248 PMC: 11162818. DOI: 10.7759/cureus.60055.

Identifying Recurrence Risk Factors in CT-Confirmed Acute Appendicitis in Adults Managed Non-operatively During the COVID-19 Pandemic.

Richards C, Pendower L, Kotecha P, Elmqvist K, Chinaka F, Tomasi I Cureus. 2022; 14(9):e28794.

PMID: 36225457 PMC: 9533956. DOI: 10.7759/cureus.28794.

Volume-outcome relation for acute appendicitis: evidence from a nationwide population-based study.

Wei P, Liu S, Keller J, Lin H PLoS One. 2013; 7(12):e52539.

PMID: 23300703 PMC: 3530440. DOI: 10.1371/journal.pone.0052539.

Appendicolith delays resolution of appendicitis following nonoperative management.

Lien W, Wang H, Liu K, Chen C J Gastrointest Surg. 2012; 16(12):2274-9.

PMID: 23007281 DOI: 10.1007/s11605-012-2032-1.

Re: Male gender is a risk factor for recurrent appendicitis following nonoperative treatment.

Di Saverio S, Coccolini F, Pisano M, Catena F, Jovine E, Tugnoli G World J Surg. 2011; 36(2):486-7.

PMID: 21947459 DOI: 10.1007/s00268-011-1278-1.

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