Lipid Complexes with Cationic Peptides and OAKs; Their Role in Antimicrobial Action and in the Delivery of Antimicrobial Agents

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2011 May 17

PMID 21573783

Citations 11

Authors

Raquel F Epand

Amram Mor

Richard M Epand

Affiliations

Soon will be listed here.

Abstract

Antimicrobial agents are toxic to bacteria by a variety of mechanisms. One mechanism that is very dependent on the lipid composition of the bacterial membrane is the clustering of anionic lipid by cationic antimicrobial agents. Certain species of oligo-acyl-lysine (OAK) antimicrobial agents are particularly effective in clustering anionic lipids in mixtures mimicking the composition of bacterial membranes. The clustering of anionic lipids by certain cationic antimicrobial agents contributes to the anti-bacterial action of these agents. Bacterial membrane lipids are a determining factor, resulting in some species of bacteria being more susceptible than others. In addition, lipids can be used to increase the effectiveness of antimicrobial agents when administered in vivo. Therefore, we review some of the structures in which lipid mixtures can assemble, to more effectively be utilized as antimicrobial delivery systems. We describe in more detail the complexes formed between mixtures of lipids mimicking bacterial membranes and an OAK and their usefulness in synergizing with antibiotics to overcome bacterial multidrug resistance.

Citing Articles

Interaction of Halictine-Related Antimicrobial Peptides with Membrane Models.

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Advances in Development of Antimicrobial Peptidomimetics as Potential Drugs.

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