Binding of GAP to Activated PDGF Receptors

Overview

Journal Science

Specialty Science

Date 1990 Mar 30

PMID 2157284

Citations 121

Authors

A Kazlauskas

C Ellis

T Pawson

J A Cooper

Affiliations

Soon will be listed here.

Abstract

The ras proto-oncogene products appear to relay intracellular signals via the Ras guanosine triphosphatase (GTPase) activator protein, GAP. In dog epithelial cells expressing human platelet-derived growth factor (PDGF) receptors, binding of PDGF caused approximately one-tenth of the total GAP molecules to complex with the receptor. Studies with mutant PDGF receptors showed that maximum association required both receptor kinase activity and phosphorylatable tyrosine residues at both the identified sites of receptor autophosphorylation.

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