Early Loss of Peritubular Capillaries After Kidney Transplantation

Overview

Journal J Am Soc Nephrol

Specialty Nephrology

Date 2011 May 14

PMID 21566051

Citations 38

Authors

Floortje M E G Steegh

Marielle A C J Gelens

Fred H M Nieman

Johannes P van Hooff

Jack P M Cleutjens

Robert Jan van Suylen

Mat J A P Daemen

Ernst L W van Heurn

Maarten H L Christiaans

Carine J Peutz-Kootstra

Affiliations

Soon will be listed here.

Abstract

Inflammation, interstitial fibrosis (IF), and tubular atrophy (TA) precede chronic transplant dysfunction, which is a major cause of renal allograft loss. There is an association between IF/TA and loss of peritubular capillaries (PTCs) in advanced renal disease, but whether PTC loss occurs in an early stage of chronic transplant dysfunction is unknown. Here, we studied PTC number, IF/TA, inflammation, and renal function in 48 patients who underwent protocol biopsies. Compared with before transplantation, there was a statistically significant loss of PTCs by 3 months after transplantation. Fewer PTCs in the 3-month biopsy correlated with high IF/TA and inflammation scores and predicted lower renal function at 1 year. Predictors of PTC loss during the first 3 months after transplantation included donor type, rejection, donor age, and the number of PTCs at the time of implantation. In conclusion, PTC loss occurs during the first 3 months after renal transplantation, associates with increased IF and TA, and predicts reduced renal function.

Citing Articles

Shape, Size, and Spatial Relationships: Peritubular Capillary Features in Kidney Fibrosis and Disease Progression.

Nast C Clin J Am Soc Nephrol. 2025; .

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Ultrasound super-resolution imaging for the assessment of renal allograft dysfunction: A pilot study.

Hu Y, Lei Y, Yu M, Zhang Y, Huang X, Zhang G Heliyon. 2024; 10(16):e36515.

PMID: 39247269 PMC: 11380004. DOI: 10.1016/j.heliyon.2024.e36515.

Characterizing hub biomarkers for post-transplant renal fibrosis and unveiling their immunological functions through RNA sequencing and advanced machine learning techniques.

Niu X, Xu C, Cheuk Y, Xu X, Liang L, Zhang P J Transl Med. 2024; 22(1):186.

PMID: 38378674 PMC: 10880303. DOI: 10.1186/s12967-024-04971-9.

The relationship of peritubular capillary density with glomerular volume and kidney function in living kidney donors.

van der Weijden J, De Hoogt P, Leufkens M, Keijbeck A, van Goor H, van den Heuvel M J Nephrol. 2023; 36(7):2111-2124.

PMID: 37768545 PMC: 10543576. DOI: 10.1007/s40620-023-01734-5.

Capillary rarefaction: a missing link in renal and cardiovascular disease?.

Steegh F, Keijbeck A, de Hoogt P, Rademakers T, Houben A, Reesink K Angiogenesis. 2023; 27(1):23-35.

PMID: 37326760 DOI: 10.1007/s10456-023-09883-8.

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