Unusual Features of Protein Interaction in Human Immunodeficiency Virus (HIV) Virions

Overview

Journal Arch Virol

Specialty Microbiology

Date 1990 Jan 1

PMID 2156489

Citations 2

Authors

A G Bukrinskaya

N K Sharova

Affiliations

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Abstract

The treatment of HIV-1 virions with ionic and nonionic detergents (NP 40, octylglucoside, Na deoxycholate) resulted in an effect unusual for enveloped viruses: instead of solubilization of glycoproteins, the core protein p24 was solubilized while envelope glycoproteins with other structural proteins were found in subviral particles. These data are consistent with a model of HIV structural organization in which glycoproteins are included in the matrix formed by the protein p 17 and suggest that p24 is neither involved in the matrix nor closely bound to any viral proteins.

Citing Articles

Vif is largely absent from human immunodeficiency virus type 1 mature virions and associates mainly with viral particles containing unprocessed gag.

Sova P, Volsky D, Wang L, Chao W J Virol. 2001; 75(12):5504-17.

PMID: 11356958 PMC: 114263. DOI: 10.1128/JVI.75.12.5504-5517.2001.

Nascent human immunodeficiency virus type 1 reverse transcription occurs within an enveloped particle.

Zhang H, Zhang Y, Spicer T, Henrard D, Poiesz B J Virol. 1995; 69(6):3675-82.

PMID: 7745716 PMC: 189083. DOI: 10.1128/JVI.69.6.3675-3682.1995.

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