De Novo Synthesis of Natural Products Via the Asymmetric Hydration of Polyenes

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2011 May 12

PMID 21559534

Citations 4

Authors

Yanping Wang

Yalan Xing

Qi Zhang

George A ODoherty

Affiliations

Soon will be listed here.

Abstract

For the last ten years our group has been working toward the development of an asymmetric hydration approach to polyketide natural products based on the regioselective hydration of di- and tri-enoates. Key to the success of this approach is the recognition that both high regiocontrol and asymmetric induction could be obtained by the use of a Sharpless asymmetric dihydroxylation reaction. Herein we describe the development of the method and its application to natural product total synthesis.

Citing Articles

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Total and Formal Syntheses of Fostriecin.

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