Epigenetic Effects and Molecular Mechanisms of Tumorigenesis Induced by Cigarette Smoke: an Overview

Overview

Journal J Oncol

Specialty Oncology

Date 2011 May 12

PMID 21559255

Citations 29

Authors

Rong-Jane Chen

Louis W Chang

Pinpin Lin

Ying-Jan Wang

Affiliations

Soon will be listed here.

Abstract

Cigarette smoking is one of the major causes of carcinogenesis. Direct genotoxicity induced by cigarette smoke leads to initiation of carcinogenesis. Nongenotoxic (epigenetic) effects of cigarette smoke also act as modulators altering cellular functions. These two effects underlie the mechanisms of tumor promotion and progression. While there is no lack of general reviews on the genotoxic and carcinogenic potentials of cigarette smoke in lung carcinogenesis, updated review on the epigenetic effects and molecular mechanisms of cigarette smoke and carcinogenesis, not limited to lung, is lacking. We are presenting a comprehensive review of recent investigations on cigarette smoke, with special attentions to nicotine, NNK, and PAHs. The current understanding on their molecular mechanisms include (1) receptors, (2) cell cycle regulators, (3) signaling pathways, (4) apoptosis mediators, (5) angiogenic factors, and (6) invasive and metastasis mediators. This review highlighted the complexity biological responses to cigarette smoke components and their involvements in tumorigenesis.

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References

Ambrose J, Barua R . The pathophysiology of cigarette smoking and cardiovascular disease: an update. J Am Coll Cardiol. 2004; 43(10):1731-7. DOI: 10.1016/j.jacc.2003.12.047. View

Lubet R, Zhang Z, Wiseman R, You M . Use of p53 transgenic mice in the development of cancer models for multiple purposes. Exp Lung Res. 2001; 26(8):581-93. DOI: 10.1080/01902140150216684. View

Dasgupta P, Chellappan S . Nicotine-mediated cell proliferation and angiogenesis: new twists to an old story. Cell Cycle. 2006; 5(20):2324-8. DOI: 10.4161/cc.5.20.3366. View

Miller M, Holloway A, Foster W . Benzo-[a]-pyrene increases invasion in MDA-MB-231 breast cancer cells via increased COX-II expression and prostaglandin E2 (PGE2) output. Clin Exp Metastasis. 2005; 22(2):149-56. DOI: 10.1007/s10585-005-6536-x. View

Askari M, Tsao M, Schuller H . The tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone stimulates proliferation of immortalized human pancreatic duct epithelia through beta-adrenergic transactivation of EGF receptors. J Cancer Res Clin Oncol. 2005; 131(10):639-48. DOI: 10.1007/s00432-005-0002-7. View

Richardson G, Tucker M, Venzon D, Linnoila R, Phelps R, Phares J . Smoking cessation after successful treatment of small-cell lung cancer is associated with fewer smoking-related second primary cancers. Ann Intern Med. 1993; 119(5):383-90. DOI: 10.7326/0003-4819-119-5-199309010-00006. View

Laag E, Majidi M, Cekanova M, Masi T, Takahashi T, Schuller H . NNK activates ERK1/2 and CREB/ATF-1 via beta-1-AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells. Int J Cancer. 2006; 119(7):1547-52. DOI: 10.1002/ijc.21987. View

Arias H, Richards V, Ng D, Ghafoori M, Le V, Mousa S . Role of non-neuronal nicotinic acetylcholine receptors in angiogenesis. Int J Biochem Cell Biol. 2009; 41(7):1441-51. DOI: 10.1016/j.biocel.2009.01.013. View

Akopyan G, Bonavida B . Understanding tobacco smoke carcinogen NNK and lung tumorigenesis. Int J Oncol. 2006; 29(4):745-52. View

10.

Cooke J, Bitterman H . Nicotine and angiogenesis: a new paradigm for tobacco-related diseases. Ann Med. 2004; 36(1):33-40. DOI: 10.1080/07853890310017576. View

11.

Penta J, Johnson F, Wachsman J, Copeland W . Mitochondrial DNA in human malignancy. Mutat Res. 2001; 488(2):119-33. DOI: 10.1016/s1383-5742(01)00053-9. View

12.

Hecht S . Cigarette smoking: cancer risks, carcinogens, and mechanisms. Langenbecks Arch Surg. 2006; 391(6):603-13. DOI: 10.1007/s00423-006-0111-z. View

13.

Tournier J, Birembaut P . Nicotinic acetylcholine receptors and predisposition to lung cancer. Curr Opin Oncol. 2010; 23(1):83-7. DOI: 10.1097/CCO.0b013e3283412ea1. View

14.

Yoshino I, Kometani T, Shoji F, Osoegawa A, Ohba T, Kouso H . Induction of epithelial-mesenchymal transition-related genes by benzo[a]pyrene in lung cancer cells. Cancer. 2007; 110(2):369-74. DOI: 10.1002/cncr.22728. View

15.

Bose C, Zhang H, Udupa K, Chowdhury P . Activation of p-ERK1/2 by nicotine in pancreatic tumor cell line AR42J: effects on proliferation and secretion. Am J Physiol Gastrointest Liver Physiol. 2005; 289(5):G926-34. DOI: 10.1152/ajpgi.00138.2005. View

16.

Oliveira P, Colaco A, Chaves R, Guedes-Pinto H, De-La-Cruz P L, Lopes C . Chemical carcinogenesis. An Acad Bras Cienc. 2007; 79(4):593-616. DOI: 10.1590/s0001-37652007000400004. View

17.

Grozio A, Paleari L, Catassi A, Servent D, Cilli M, Piccardi F . Natural agents targeting the alpha7-nicotinic-receptor in NSCLC: a promising prospective in anti-cancer drug development. Int J Cancer. 2007; 122(8):1911-5. DOI: 10.1002/ijc.23298. View

18.

Martinez-Garcia E, Irigoyen M, Gonzalez-Moreno O, Corrales L, Teijeira A, Salvo E . Repetitive nicotine exposure leads to a more malignant and metastasis-prone phenotype of SCLC: a molecular insight into the importance of quitting smoking during treatment. Toxicol Sci. 2010; 116(2):467-76. DOI: 10.1093/toxsci/kfq138. View

19.

Tsurutani J, Castillo S, Brognard J, Granville C, Zhang C, Gills J . Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells. Carcinogenesis. 2005; 26(7):1182-95. DOI: 10.1093/carcin/bgi072. View

20.

Schuller H, Porter B, Riechert A . Beta-adrenergic modulation of NNK-induced lung carcinogenesis in hamsters. J Cancer Res Clin Oncol. 2000; 126(11):624-30. DOI: 10.1007/pl00008474. View