HOXB5 Expression in Oral Squamous Cell Carcinoma

Overview

Journal J Appl Oral Sci

Specialty Dentistry

Date 2011 May 10

PMID 21552713

Citations 13

Authors

Renata Tucci

Marcia Sampaio Campos

Luciana Fasanella Matizonkas-Antonio

Marcelo Durazzo

Decio Dos Santos Pinto Junior

Fabio Daumas Nunes

Affiliations

Soon will be listed here.

Abstract

Unlabelled: Human HOX genes encode transcription factors that act as master regulators of embryonic development. They are important in several processes such as cellular morphogenesis and differentiation. The HOXB5 gene in particular has been reported in some types of neoplasm, but not in oral cancer.

Objective: The present study investigated the expression of HOXB5 in oral squamous cell carcinoma (SCC) and in non-tumoral adjacent tissues, focusing on verifying its possible role as a broad tumor-associated gene and its association with histopathological and clinical (TNM) characteristics.

Material And Methods: RT-PCR was performed to amplify HOXB5 mRNA in 15 OSCCs and adjacent non-tumoral epithelium. A possible association with TNM and histopathologic data was verified by the chi-square and post-hoc t-test.

Results: HOXB5 was amplified in 60% non-tumoral epithelium and in 93.3% carcinomas. No statistically significant differences were found regarding the HOXB5 mRNA expression and TNM or histological grade.

Conclusion: HOXB5 is expressed in OSCCs and its role in cancer progression should be further investigated.

Citing Articles

HOXB5-activated ANGPT2 promotes the proliferation, migration, invasion and angiogenic effect of esophageal cancer cells via activating ERK/AKT signaling pathway.

Li J, Gao S Exp Ther Med. 2022; 24(3):585.

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Multitranscriptome analyses of keloid fibroblasts reveal the role of the HIF-1α/HOXC6/ERK axis in keloid development.

Wang Q, Zhong Y, Li Z, Zhu D, Lu H, Chen P Burns Trauma. 2022; 10:tkac013.

PMID: 35547861 PMC: 9085412. DOI: 10.1093/burnst/tkac013.

HOXB4 promotes the malignant progression of ovarian cancer via DHDDS.

Li N, Gou J, Xiong J, You J, Li Z BMC Cancer. 2020; 20(1):222.

PMID: 32178630 PMC: 7077141. DOI: 10.1186/s12885-020-06725-4.

HOXC6 gene silencing inhibits epithelial-mesenchymal transition and cell viability through the TGF-β/smad signaling pathway in cervical carcinoma cells.

Zhang F, Ren C, Liu L, Chen Y, Yang L, Zhang X Cancer Cell Int. 2018; 18:204.

PMID: 30559605 PMC: 6290547. DOI: 10.1186/s12935-018-0680-2.

HOXB5 promotes retinoblastoma cell migration and invasion via ERK1/2 pathway-mediated MMPs production.

Xu H, Zhao H, Yu J Am J Transl Res. 2018; 10(6):1703-1712.

PMID: 30018711 PMC: 6038074.

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