Pure Red Cell Aplasia Caused by Pegylated Interferon-α-2a Plus Ribavirin in the Treatment of Chronic Hepatitis C

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2011 May 7

PMID 21547138

Citations 4

Authors

Cheng-Shyong Chang

Sheng-Lei Yan

Hsuan-Yu Lin

Fu-Lien Yu

Chien-Yu Tsai

Affiliations

Soon will be listed here.

Abstract

Pure red cell aplasia (PRCA) is a rare hematological disorder which is characterized by severe anemia, reticulocytopenia and almost complete absence of erythroid precursors in bone marrow. The pathophysiology of PRCA may be congenital or acquired. To our knowledge, there is only one case report in the English literature of PRCA after pegylated interferon combination therapy for chronic hepatitis C. We report a second case of PRCA after pegylated interferon combination treatment for chronic hepatitis C. The diagnosis of PRCA was confirmed by the typical findings of bone marrow biopsy. The possible etiologies of our case are also discussed in this paper.

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