» Articles » PMID: 21547092

Diagnosis and Management of Fetal Growth Restriction

Overview
Journal J Pregnancy
Publisher Wiley
Date 2011 May 7
PMID 21547092
Citations 58
Authors
Affiliations
Soon will be listed here.
Abstract

Fetal growth restriction (FGR) remains a leading contributor to perinatal mortality and morbidity and metabolic syndrome in later life. Recent advances in ultrasound and Doppler have elucidated several mechanisms in the evolution of the disease. However, consistent classification and characterization regarding the severity of FGR is lacking. There is no cure, and management is reliant on a structured antenatal surveillance program with timely intervention. Hitherto, the time to deliver is an enigma. In this paper, the challenges in the diagnosis and management of FGR are discussed. The biophysical profile, Doppler, biochemical and molecular technologies that may refine management are reviewed. Finally, a model pathway for the clinical management of pregnancies complicated by FGR is presented.

Citing Articles

Mid-Pregnancy Placental Transcriptome in a Model of Placental Insufficiency with and without Novel Intervention.

Wilson R, Davenport B, Jones H Reprod Sci. 2024; 32(2):435-443.

PMID: 39707140 DOI: 10.1007/s43032-024-01769-4.


The role of microRNAs in pregnancies complicated by maternal diabetes.

Owen M, Kennedy M, Quilang R, Scott E, Forbes K Clin Sci (Lond). 2024; 138(18):1179-1207.

PMID: 39289953 PMC: 11409017. DOI: 10.1042/CS20230681.


Maternal Age at Menarche Genes Determines Fetal Growth Restriction Risk.

Reshetnikov E, Churnosova M, Reshetnikova Y, Stepanov V, Bocharova A, Serebrova V Int J Mol Sci. 2024; 25(5).

PMID: 38473894 PMC: 10932237. DOI: 10.3390/ijms25052647.


Trauma and Posttraumatic Stress Disorder as Important Risk Factors for Gestational Metabolic Dysfunction.

Rocha M, Daniels K, Chandrasekaran S, Michopoulos V Am J Perinatol. 2024; 41(14):1895-1907.

PMID: 38307105 PMC: 11436347. DOI: 10.1055/a-2260-5051.


Use of Photoacoustic Imaging to Study the Effects of Anemia on Placental Oxygen Saturation in Normoxic and Hypoxic Conditions.

Noble R, Kirschenman R, Wiedemeyer A, Patel V, Rachid J, Zemp R Reprod Sci. 2023; 31(4):966-974.

PMID: 38012522 DOI: 10.1007/s43032-023-01395-6.


References
1.
Baschat A, Gembruch U, Harman C . The sequence of changes in Doppler and biophysical parameters as severe fetal growth restriction worsens. Ultrasound Obstet Gynecol. 2002; 18(6):571-7. DOI: 10.1046/j.0960-7692.2001.00591.x. View

2.
Mook-Kanamori D, Steegers E, Eilers P, Raat H, Hofman A, Jaddoe V . Risk factors and outcomes associated with first-trimester fetal growth restriction. JAMA. 2010; 303(6):527-34. DOI: 10.1001/jama.2010.78. View

3.
Pilalis A, Souka A, Antsaklis P, Daskalakis G, Papantoniou N, Mesogitis S . Screening for pre-eclampsia and fetal growth restriction by uterine artery Doppler and PAPP-A at 11-14 weeks' gestation. Ultrasound Obstet Gynecol. 2007; 29(2):135-40. DOI: 10.1002/uog.3881. View

4.
Hecher K, Bilardo C, Stigter R, Ville Y, Hackeloer B, Kok H . Monitoring of fetuses with intrauterine growth restriction: a longitudinal study. Ultrasound Obstet Gynecol. 2002; 18(6):564-70. DOI: 10.1046/j.0960-7692.2001.00590.x. View

5.
Dugoff L, Lynch A, Cioffi-Ragan D, Hobbins J, Schultz L, Malone F . First trimester uterine artery Doppler abnormalities predict subsequent intrauterine growth restriction. Am J Obstet Gynecol. 2005; 193(3 Pt 2):1208-12. DOI: 10.1016/j.ajog.2005.06.054. View