Extranodal NK/T-cell Lymphoma: Toward the Identification of Clinical Molecular Targets

Overview

Journal J Biomed Biotechnol

Specialty Biology

Date 2011 May 5

PMID 21541194

Citations 13

Authors

Christian Schmitt

Nouhoum Sako

Martine Bagot

Yenlin Huang

Philippe Gaulard

Armand Bensussan

Affiliations

Soon will be listed here.

Abstract

Extranodal natural killer (NK)/T-cell lymphoma of nasal type (NKTCL) is a malignant disorder of cytotoxic lymphocytes of NK or more rarely T cells associated with clonal Epstein-Barr virus infection. Extranodal NKTCL is rare in Western countries, but in Asia and Central and South America it can account for up to 10% of non-Hodgkin's lymphomas. It is an aggressive neoplasm with very poor prognosis. Although the pathogenesis of extranodal NKTCL remains poorly understood, some insights have been gained in the recent years, especially from genome-wide studies. Based on our own experience and knowledge of the literature, we here review some of the genomic and functional pathway alterations observed in NKTCL that could provide a rationale for the development of innovative therapeutic strategies.

Citing Articles

Comparative Analysis of the Clinical Manifestations of Sinonasal Natural Killer T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma.

Shin C, Aloraimi M, Kim T, Yu M J Rhinol. 2024; 31(2):93-100.

PMID: 39664407 PMC: 11566532. DOI: 10.18787/jr.2024.00017.

Activated hippo signal pathway inhibits cell proliferation and promotes apoptosis in NK/T cell lymphoma cells.

Chang Y, Fu X, Cui M, Li W, Zhang L, Li X Cancer Med. 2019; 8(8):3892-3904.

PMID: 31124291 PMC: 6639190. DOI: 10.1002/cam4.2174.

Molecular pathogenic pathways in extranodal NK/T cell lymphoma.

De Mel S, Hue S, Jeyasekharan A, Chng W, Ng S J Hematol Oncol. 2019; 12(1):33.

PMID: 30935402 PMC: 6444858. DOI: 10.1186/s13045-019-0716-7.

The Genomics and Molecular Biology of Natural Killer/T-Cell Lymphoma: Opportunities for Translation.

De Mel S, Soon G, Mok Y, Chung T, Jeyasekharan A, Chng W Int J Mol Sci. 2018; 19(7).

PMID: 29966370 PMC: 6073933. DOI: 10.3390/ijms19071931.

Novel findings from the Asian Lymphoma Study Group: focus on T and NK-cell lymphomas.

Chan J, Lim S Int J Hematol. 2018; 107(4):413-419.

PMID: 29380182 DOI: 10.1007/s12185-018-2406-6.

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