Osteoporosis in Diabetes Mellitus: Possible Cellular and Molecular Mechanisms

Overview

Journal World J Diabetes

Publisher Baishideng Publishing Group

Specialty Endocrinology

Date 2011 May 4

PMID 21537459

Citations 69

Authors

Kannikar Wongdee

Narattaphol Charoenphandhu

Affiliations

Soon will be listed here.

Abstract

Osteoporosis, a global age-related health problem in both male and female elderly, insidiously deteriorates the microstructure of bone, particularly at trabecular sites, such as vertebrae, ribs and hips, culminating in fragility fractures, pain and disability. Although osteoporosis is normally associated with senescence and estrogen deficiency, diabetes mellitus (DM), especially type 1 DM, also contributes to and/or aggravates bone loss in osteoporotic patients. This topic highlight article focuses on DM-induced osteoporosis and DM/osteoporosis comorbidity, covering alterations in bone metabolism as well as factors regulating bone growth under diabetic conditions including, insulin, insulin-like growth factor-1 and angiogenesis. Cellular and molecular mechanisms of DM-related bone loss are also discussed. This information provides a foundation for the better understanding of diabetic complications and for development of early screening and prevention of osteoporosis in diabetic patients.

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References

Kovacs C . Calcium and bone metabolism during pregnancy and lactation. J Mammary Gland Biol Neoplasia. 2005; 10(2):105-18. DOI: 10.1007/s10911-005-5394-0. View

Silva M, Brodt M, Lynch M, McKenzie J, Tanouye K, Nyman J . Type 1 diabetes in young rats leads to progressive trabecular bone loss, cessation of cortical bone growth, and diminished whole bone strength and fatigue life. J Bone Miner Res. 2009; 24(9):1618-27. PMC: 2730931. DOI: 10.1359/jbmr.090316. View

Kim S, Choung S . Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice. Arch Pharm Res. 2010; 33(2):325-33. DOI: 10.1007/s12272-010-0219-0. View

Nuntapornsak A, Wongdee K, Thongbunchoo J, Krishnamra N, Charoenphandhu N . Changes in the mRNA expression of osteoblast-related genes in response to beta(3)-adrenergic agonist in UMR106 cells. Cell Biochem Funct. 2009; 28(1):45-51. DOI: 10.1002/cbf.1617. View

To W, Wong M . Bone mineral density changes in gestational diabetic pregnancies-a longitudinal study using quantitative ultrasound measurements of the os calcis. Gynecol Endocrinol. 2008; 24(9):519-25. DOI: 10.1080/09513590802288184. View

Saito M, Marumo K . Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus. Osteoporos Int. 2009; 21(2):195-214. DOI: 10.1007/s00198-009-1066-z. View

Amin A, Abd Elmageed Z, Nair D, Partyka M, Kadowitz P, Belmadani S . Modified multipotent stromal cells with epidermal growth factor restore vasculogenesis and blood flow in ischemic hind-limb of type II diabetic mice. Lab Invest. 2010; 90(7):985-96. PMC: 3154725. DOI: 10.1038/labinvest.2010.86. View

Ragab A, Nalepka J, Bi Y, Greenfield E . Cytokines synergistically induce osteoclast differentiation: support by immortalized or normal calvarial cells. Am J Physiol Cell Physiol. 2002; 283(3):C679-87. DOI: 10.1152/ajpcell.00421.2001. View

Mastrandrea L, Wactawski-Wende J, Donahue R, Hovey K, Clark A, Quattrin T . Young women with type 1 diabetes have lower bone mineral density that persists over time. Diabetes Care. 2008; 31(9):1729-35. PMC: 2518333. DOI: 10.2337/dc07-2426. View

10.

Yaturu S, Humphrey S, Landry C, Jain S . Decreased bone mineral density in men with metabolic syndrome alone and with type 2 diabetes. Med Sci Monit. 2008; 15(1):CR5-9. View

11.

Merlotti D, Gennari L, Dotta F, Lauro D, Nuti R . Mechanisms of impaired bone strength in type 1 and 2 diabetes. Nutr Metab Cardiovasc Dis. 2010; 20(9):683-90. DOI: 10.1016/j.numecd.2010.07.008. View

12.

Zhang M, Xuan S, Bouxsein M, von Stechow D, Akeno N, Faugere M . Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization. J Biol Chem. 2002; 277(46):44005-12. DOI: 10.1074/jbc.M208265200. View

13.

Soto N, Pruzzo R, Eyzaguirre F, Iniguez G, Lopez P, Mohr J . Bone mass and sex steroids in postmenarcheal adolescents and adult women with Type 1 diabetes mellitus. J Diabetes Complications. 2009; 25(1):19-24. DOI: 10.1016/j.jdiacomp.2009.10.002. View

14.

Debiais F . Thiazolidinediones: antidiabetic agents with effects on bone. Joint Bone Spine. 2009; 76(3):221-3. DOI: 10.1016/j.jbspin.2009.01.005. View

15.

Botolin S, Faugere M, Malluche H, Orth M, Meyer R, McCabe L . Increased bone adiposity and peroxisomal proliferator-activated receptor-gamma2 expression in type I diabetic mice. Endocrinology. 2005; 146(8):3622-31. PMC: 1242186. DOI: 10.1210/en.2004-1677. View

16.

Tomasek J, Meyers S, Basinger J, Green D, Shew R . Diabetic and age-related enhancement of collagen-linked fluorescence in cortical bones of rats. Life Sci. 1994; 55(11):855-61. DOI: 10.1016/0024-3205(94)90041-8. View

17.

Pogoda P, Priemel M, Rueger J, Amling M . Bone remodeling: new aspects of a key process that controls skeletal maintenance and repair. Osteoporos Int. 2004; 16 Suppl 2:S18-24. DOI: 10.1007/s00198-004-1787-y. View

18.

Inzerillo A, Epstein S . Osteoporosis and diabetes mellitus. Rev Endocr Metab Disord. 2004; 5(3):261-8. DOI: 10.1023/B:REMD.0000032415.83124.20. View

19.

Supanchart C, Kornak U . Ion channels and transporters in osteoclasts. Arch Biochem Biophys. 2008; 473(2):161-5. DOI: 10.1016/j.abb.2008.03.029. View

20.

Yamaguchi T, Kanazawa I, Yamamoto M, Kurioka S, Yamauchi M, Yano S . Associations between components of the metabolic syndrome versus bone mineral density and vertebral fractures in patients with type 2 diabetes. Bone. 2009; 45(2):174-9. DOI: 10.1016/j.bone.2009.05.003. View