Proton-induced Dismutation of Superoxide in Aprotic Media by Bile Pigments

Overview

Journal Experientia

Specialty Science

Date 1990 Jan 15

PMID 2153572

Authors

J M Ribo

J A Farrera

J Claret

Affiliations

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Abstract

Cyclic voltammetry of molecular oxygen in aprotic media (dimethylformamide) and in the presence of bilirubin and other bile pigments shows that superoxide anion (O2-.) undergoes proton-induced dismutation. Lactam hydrogens of bile pigments are sufficiently acid to induce (O2-.) disproportionation to O2 and H2O2. Because of its characteristic lipophilic behavior, a biological role for natural bilirubin similar to that of other non-enzymatic lipophilic scavengers of (O2-.) is suggested.

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