ATM Protein Kinase: the Linchpin of Cellular Defenses to Stress

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2011 May 3

PMID 21533982

Citations 56

Authors

Shahzad Bhatti

Sergei Kozlov

Ammad Ahmad Farooqi

Ali Naqi

Martin Lavin

Kum Kum Khanna

Affiliations

Soon will be listed here.

Abstract

ATM is the most significant molecule involved in monitoring the genomic integrity of the cell. Any damage done to DNA relentlessly challenges the cellular machinery involved in recognition, processing and repair of these insults. ATM kinase is activated early to detect and signal lesions in DNA, arrest the cell cycle, establish DNA repair signaling and faithfully restore the damaged chromatin. ATM activation plays an important role as a barrier to tumorigenesis, metabolic syndrome and neurodegeneration. Therefore, studies of ATM-dependent DNA damage signaling pathways hold promise for treatment of a variety of debilitating diseases through the development of new therapeutics capable of modulating cellular responses to stress. In this review, we have tried to untangle the complex web of ATM signaling pathways with the purpose of pinpointing multiple roles of ATM underlying the complex phenotypes observed in AT patients.

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