Proteomics and Mass Spectrometry: What Have We Learned About the Heart?

Overview

Journal Curr Cardiol Rev

Publisher Bentham Science Publishers

Specialty Cardiology & Vascular Diseases

Date 2011 May 3

PMID 21532779

Citations 8

Authors

Shaan Chugh

Colin Suen

Anthony Gramolini

Affiliations

Soon will be listed here.

Abstract

The emergence of new platforms for the discovery of innovative therapeutics has provided a means for diagnosing cardiac disease in its early stages. Taking into consideration the global health burden of cardiac disease, clinicians require innovations in medical diagnostics that can be used for risk stratification. Proteomic based studies offer an avenue for the discovery of proteins that are differentially regulated during disease; such proteins could serve as novel biomarkers of the disease state. For instance, in clinical practice, the abundance of such biomarkers in blood could be correlated with the severity of the disease state. As such, early detection of biomarkers would enable an improvement in patient prognosis. In this review, we outline advancements in various proteomic platforms used to study the disease proteome and their applications to the field of clinical medicine. Specifically, we highlight the contributions of proteomic-based profiling experiments to the analysis of cardiovascular diseases.

Citing Articles

High-Field Asymmetric Waveform Ion Mobility Spectrometry: Practical Alternative for Cardiac Proteome Sample Processing.

Ai L, Binek A, Kreimer S, Ayres M, Stotland A, Van Eyk J J Proteome Res. 2023; 22(6):2124-2130.

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Trends in mass spectrometry imaging for cardiovascular diseases.

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Taking Systems Medicine to Heart.

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The use of biophysical proteomic techniques in advancing our understanding of diseases.

Xu Q, Cui Z, Venkatraman G, Gomes A Biophys Rev. 2017; 4(2):125-135.

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Cardiovascular consequences of metabolic syndrome.

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