Plasticity of Human Menstrual Blood Stem Cells Derived from the Endometrium

Overview

Journal J Zhejiang Univ Sci B

Specialties Biology
General Medicine

Date 2011 Apr 30

PMID 21528491

Citations 20

Authors

Jian Lin

Dennis Xiang

Jin-Long Zhang

Julie Allickson

Charlie Xiang

Affiliations

Soon will be listed here.

Abstract

Stem cells can be obtained from women's menstrual blood derived from the endometrium. The cells display stem cell markers such as Oct-4, SSEA-4, Nanog, and c-kit (CD117), and have the potent ability to differentiate into various cell types, including the heart, nerve, bone, cartilage, and fat. There has been no evidence of teratoma, ectopic formation, or any immune response after transplantation into an animal model. These cells quickly regenerate after menstruation and secrete many growth factors to display recurrent angiogenesis. The plasticity and safety of the acquired cells have been demonstrated in many studies. Menstrual blood-derived stem cells (MenSCs) provide an alternative source of adult stem cells for research and application in regenerative medicine. Here we summarize the multipotent properties and the plasticities of MenSCs and other endometrial stem cells from recent studies conducted both in vitro and in vivo.

Citing Articles

Uterine Biosynthesis through Tissue Engineering: An Overview of Current Methods and Status.

Sanjeev K, Guruprasad M, Vikram R, Priyadarshini S, Mazumder A, Inderchand M Curr Pharm Biotechnol. 2024; 26(2):208-221.

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Menstrual blood-derived endometrial stem cell, a unique and promising alternative in the stem cell-based therapy for chemotherapy-induced premature ovarian insufficiency.

Zhang S, Yahaya B, Pan Y, Liu Y, Lin J Stem Cell Res Ther. 2023; 14(1):327.

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Systemic delivery of menstrual blood stem cells is more effective in preventing remote organ injuries following myocardial infarction in comparison with bone marrow stem cells in rat.

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Comparative study of three types of mesenchymal stem cell to differentiate into pancreatic β-like cells .

Mo Y, Wang Z, Gao J, Yan Y, Ren H, Zhang F Exp Ther Med. 2021; 22(3):936.

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Menstrual Blood-Derived Endometrial Stem Cells' Impact for the Treatment Perspective of Female Infertility.

Skliute G, Bausyte R, Borutinskaite V, Valiuliene G, Kaupinis A, Valius M Int J Mol Sci. 2021; 22(13).

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