Detecting, Studying, and Treating Autism Early: the One-year Well-baby Check-up Approach

Overview

Journal J Pediatr

Specialty Pediatrics

Date 2011 Apr 29

PMID 21524759

Citations 104

Authors

Karen Pierce

Cindy Carter

Melanie Weinfeld

Jamie Desmond

Roxana Hazin

Robert Bjork

Nicole Gallagher

Affiliations

Soon will be listed here.

Abstract

Objectives: To determine the feasibility of implementing a broadband screen at the 1-year check-up to detect cases of autism spectrum disorders (ASD), language delay (LD), and developmental delay (DD).

Study Design: The Communication and Symbolic Behavior Scales Developmental Profile Infant-Toddler Checklist was distributed at every 1-year pediatric check-up; 137 pediatricians and 225 infants participated. Screens were scored immediately, and failures referred for further evaluation.

Results: Pediatricians screened 10 479 infants at the 1-year check-up; 184 infants who failed the screen were evaluated and tracked. To date, 32 infants received a provisional or final diagnosis of ASD, 56 of LD, nine of DD, and 36 of "other." Five infants who initially tested positive for ASD no longer met criteria at follow-up. The remainder of the sample was false positive results. Positive predictive value was estimated to be .75.

Conclusions: The 1-Year Well-Baby Check-Up Approach shows promise as a simple mechanism to detect cases of ASD, LD, and DD at 1 year. This procedure offers an alternative to the baby sibling design as a mechanism to study autism prospectively, the results of which will enrich our understanding of autism at an early age.

Citing Articles

Investigating the Predictive Validity of the Quantitative Checklist for Autism in Toddlers and the Autism Diagnostic Observation Schedule-2 in Children at Elevated Likelihood for Autism.

Schaubroeck S, Demurie E, Begum-Ali J, Bolte S, Boterberg S, Buitelaar J J Autism Dev Disord. 2024; .

PMID: 39397184 DOI: 10.1007/s10803-024-06585-y.

A 3D approach to understanding heterogeneity in early developing autisms.

Mandelli V, Severino I, Eyler L, Pierce K, Courchesne E, Lombardo M Mol Autism. 2024; 15(1):41.

PMID: 39350293 PMC: 11443946. DOI: 10.1186/s13229-024-00613-5.

Sensorimotor variability distinguishes early features of cognition in toddlers with autism.

Denisova K, Wolpert D iScience. 2024; 27(9):110685.

PMID: 39252975 PMC: 11381898. DOI: 10.1016/j.isci.2024.110685.

Differences in regional brain structure in toddlers with autism are related to future language outcomes.

Duan K, Eyler L, Pierce K, Lombardo M, Datko M, Hagler D Nat Commun. 2024; 15(1):5075.

PMID: 38871689 PMC: 11176156. DOI: 10.1038/s41467-024-48952-4.

Autism Detection in Early Childhood (ADEC) in a Low-Income Spanish-Speaking Population in Guayaquil (Ecuador).

Mata-Iturralde S, Alonso-Esteban Y, Alcantud-Marin F, Young R J Autism Dev Disord. 2024; .

PMID: 38819703 DOI: 10.1007/s10803-024-06413-3.

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