Resistance Class 1 Integron in Clinical Methicillin-resistant Staphylococcus Aureus Strains in Southern China, 2001-2006

Overview

Journal Clin Microbiol Infect

Publisher Elsevier

Specialty Infectious Diseases

Date 2011 Apr 28

PMID 21521411

Citations 46

Authors

Z Xu

L Li

M E Shirtliff

B M Peters

B Li

Y Peng

M J Alam

S Yamasaki

L Shi

Affiliations

Soon will be listed here.

Abstract

As a novel antibiotic resistance determinant, investigation of the occurrence and characteristics of class 1 integron was performed on nosocomial methicillin-resistant Staphylococcus aureus (MRSA) strains sampled during 2001-2006. Seventy-six out of 179 (42.5%) of the tested strains were found to carry class 1 integrons, with four unique arrays of gene cassettes detected. This is the first report of the comprehensive identification and typing of class 1 integrons in clinical MRSA isolates over a 6-year period, representing the first evidence for class 1 integrons as possible antibiotic resistance determinants in clinical MRSA strains.

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