Osteonecrosis in Children After Therapy for Malignancy

Overview

Journal AJR Am J Roentgenol

Specialties Oncology
Radiology

Date 2011 Apr 23

PMID 21512065

Citations 21

Authors

Sue C Kaste

Evguenia J Karimova

Michael D Neel

Affiliations

Soon will be listed here.

Abstract

Objective: Osteonecrosis in the growing population of childhood cancer survivors results from disease and treatment. Imagers must be knowledgeable about patient groups at risk for its development, patterns of involvement and potential implications. This review will focus on implications of this potentially life-altering toxicity.

Conclusion: Childhood cancer survivors are at increased risk for developing osteonecrosis. Because osteonecrosis is often asymptomatic until late in the process, imaging is critical for its detection and characterization when interventions may be most effective to ameliorate its progression.

Citing Articles

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Functional Outcomes for Children, Adolescents, and Young Adults with Osteonecrosis following Hip Core Decompression.

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References

Balduzzi A, Gooley T, Anasetti C, Sanders J, Martin P, Petersdorf E . Unrelated donor marrow transplantation in children. Blood. 1995; 86(8):3247-56. View

Castro T, Lederman H, Terreri M, Kaste S, Hilario M . Detection of multifocal osteonecrosis in an adolescent with dermatomyositis using whole-body MRI. Pediatr Radiol. 2010; 40(9):1566-8. DOI: 10.1007/s00247-010-1636-4. View

Sakai T, Sugano N, Nishii T, Haraguchi K, Yoshikawa H, Ohzono K . Bone scintigraphy for osteonecrosis of the knee in patients with non-traumatic osteonecrosis of the femoral head: comparison with magnetic resonance imaging. Ann Rheum Dis. 2000; 60(1):14-20. PMC: 1753361. DOI: 10.1136/ard.60.1.14. View

Burger B, Beier R, Zimmermann M, Beck J, Reiter A, Schrappe M . Osteonecrosis: a treatment related toxicity in childhood acute lymphoblastic leukemia (ALL)--experiences from trial ALL-BFM 95. Pediatr Blood Cancer. 2004; 44(3):220-5. DOI: 10.1002/pbc.20244. View

Hong J, Kim T, Kim H, Park E, Yang E, Kim S . Genetic association of angiogenesis- and hypoxia-related gene polymorphisms with osteonecrosis of the femoral head. Exp Mol Med. 2010; 42(5):376-85. PMC: 2877256. DOI: 10.3858/emm.2010.42.5.039. View

Karimova E, Kaste S . MR imaging of osteonecrosis of the knee in children with acute lymphocytic leukemia. Pediatr Radiol. 2007; 37(11):1140-6. DOI: 10.1007/s00247-007-0579-x. View

Li X, Qi J, Xia L, Li H, Hu J, Yu C . Diffusion MRI in ischemic epiphysis of the femoral head: an experimental study. J Magn Reson Imaging. 2008; 28(2):471-7. DOI: 10.1002/jmri.21458. View

Karimova E, Rai S, Ingle D, Ralph A, Deng X, Neel M . MRI of knee osteonecrosis in children with leukemia and lymphoma: Part 2, clinical and imaging patterns. AJR Am J Roentgenol. 2006; 186(2):477-82. DOI: 10.2214/AJR.04.1597. View

Bassounas A, Karantanas A, Fotiadis D, Malizos K . Femoral head osteonecrosis: volumetric MRI assessment and outcome. Eur J Radiol. 2007; 63(1):10-5. DOI: 10.1016/j.ejrad.2007.03.028. View

10.

Sheng H, Zhang G, Wang Y, Yeung D, Griffith J, Leung K . Functional perfusion MRI predicts later occurrence of steroid-associated osteonecrosis: an experimental study in rabbits. J Orthop Res. 2008; 27(6):742-7. DOI: 10.1002/jor.20765. View

11.

French D, Hamilton L, Mattano Jr L, Sather H, Devidas M, Nachman J . A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group. Blood. 2008; 111(9):4496-9. PMC: 2343589. DOI: 10.1182/blood-2007-11-123885. View

12.

Warwick B, Caristo V, Hartin N, Ihsleish W, Perera C, Van der Wall H . MRI-negative, bone scintigram-positive in early osteonecrosis of the knees. Clin Nucl Med. 2006; 31(12):750-3. DOI: 10.1097/01.rlu.0000246890.17699.2a. View

13.

Malizos K, Karantanas A, Varitimidis S, Dailiana Z, Bargiotas K, Maris T . Osteonecrosis of the femoral head: etiology, imaging and treatment. Eur J Radiol. 2007; 63(1):16-28. DOI: 10.1016/j.ejrad.2007.03.019. View

14.

Arico M, Boccalatte M, Silvestri D, Barisone E, Messina C, Chiesa R . Osteonecrosis: An emerging complication of intensive chemotherapy for childhood acute lymphoblastic leukemia. Haematologica. 2003; 88(7):747-53. View

15.

Nam K, Kim Y, Yoo J, Koo K, Yoon K, Kim H . Fate of untreated asymptomatic osteonecrosis of the femoral head. J Bone Joint Surg Am. 2008; 90(3):477-84. DOI: 10.2106/JBJS.F.01582. View

16.

Glueck C, FREIBERG R, Fontaine R, Tracy T, Wang P . Hypofibrinolysis, thrombophilia, osteonecrosis. Clin Orthop Relat Res. 2001; (386):19-33. DOI: 10.1097/00003086-200105000-00004. View

17.

Patyna S, Arrigoni C, Terron A, Kim T, Heward J, Vonderfecht S . Nonclinical safety evaluation of sunitinib: a potent inhibitor of VEGF, PDGF, KIT, FLT3, and RET receptors. Toxicol Pathol. 2008; 36(7):905-16. DOI: 10.1177/0192623308326151. View

18.

Ojala A, Paakko E, Lanning F, Lanning M . Osteonecrosis during the treatment of childhood acute lymphoblastic leukemia: a prospective MRI study. Med Pediatr Oncol. 1999; 32(1):11-7. DOI: 10.1002/(sici)1096-911x(199901)32:1<11::aid-mpo4>3.0.co;2-f. View

19.

Wheeler M . Physical changes of puberty. Endocrinol Metab Clin North Am. 1991; 20(1):1-14. View

20.

Karimova E, Rai S, Deng X, Ingle D, Ralph A, Neel M . MRI of knee osteonecrosis in children with leukemia and lymphoma: Part 1, observer agreement. AJR Am J Roentgenol. 2006; 186(2):470-6. DOI: 10.2214/AJR.04.1598. View